Pieter Leyssen

α-Ketoamides as Broad-Spectrum Inhibitors of Coronavirus and Enterovirus Replication: Structure-Based Design, Synthesis, and Activity Assessment

Linlin Zhang, Daizong Lin, Yuri Kusov et al. · Journal of Medicinal Chemistry · 2020 · 593 citations · Full text

Remdesivir, Molnupiravir and Nirmatrelvir remain active against SARS-CoV-2 Omicron and other variants of concern

Laura Vangeel, Winston Chiu, Steven De Jonghe et al. · Antiviral Research · 2022 · 424 citations · Full text

Bioactivity-Based Molecular Networking for the Discovery of Drug Leads in Natural Product Bioassay-Guided Fractionation

Louis‐Félix Nothias, Mélissa Nothias-Esposito, Ricardo Silva et al. · Journal of Natural Products · 2018 · 388 citations · Full text

Hit Identification, Lead Identification, Medicinal Chemistry +18

The Predominant Mechanism by Which Ribavirin Exerts Its Antiviral Activity In Vitro against Flaviviruses and Paramyxoviruses Is Mediated by Inhibition of IMP Dehydrogenase

Pieter Leyssen, Jan Balzarini, Erik De Clercq et al. · Journal of Virology · 2005 · 290 citations · Full text

STAT2 signaling restricts viral dissemination but drives severe pneumonia in SARS-CoV-2 infected hamsters

Robbert Boudewijns, Hendrik Jan Thibaut, Suzanne J. F. Kaptein et al. · Nature Communications · 2020 · 287 citations · Full text