Wandong Wen

Substituted indoles as selective protease activated receptor 4 (PAR-4) antagonists: Discovery and SAR of ML354

Wandong Wen, Summer E. Young, Matthew T. Duvernay et al. · Bioorganic & Medicinal Chemistry Letters · 2014 · 41 citations · Full text

Molecular Pharmacology, Substituted Indoles, Biochemistry +7

Discovery of ‘molecular switches’ within a GIRK activator scaffold that afford selective GIRK inhibitors

Wandong Wen, Wenjun Wu, Ian M. Romaine et al. · Bioorganic & Medicinal Chemistry Letters · 2013 · 27 citations · Full text

Molecular Pharmacology, Biochemistry, Natural Sciences +9

Discovery of potent and selective GIRK1/2 modulators via ‘molecular switches’ within a series of 1-(3-cyclopropyl-1-phenyl-1H-pyrazol-5-yl)ureas

Wandong Wen, Wenjun Wu, C. David Weaver et al. · Bioorganic & Medicinal Chemistry Letters · 2014 · 17 citations · Full text

Combinatorial Chemistry, Molecular Pharmacology, Biochemistry +8

Discovery and Characterization of 2‐(Cyclopropanesulfonamido)‐<i>N</i>‐(2‐ethoxyphenyl)benzamide, ML382: a Potent and Selective Positive Allosteric Modulator of MrgX1

Wandong Wen, Yan Wang, Zhe Li et al. · ChemMedChem · 2014 · 14 citations · Full text

Development of a Series of (1-Benzyl-3-(6-methoxypyrimidin-3-yl)-5-(trifluoromethoxy)-1<i>H</i>-indol-2-yl)methanols as Selective Protease Activated Receptor 4 (PAR4) Antagonists with in Vivo Utility and Activity Against γ-Thrombin

Kayla J. Temple, Matthew T. Duvernay, Summer E. Young et al. · Journal of Medicinal Chemistry · 2016 · 14 citations · Full text

Peptide Science, Pharmacotherapy, Par4 Ic50 +22