C.J. Hardy

Optimization of Novel Indazoles as Highly Potent and Selective Inhibitors of Phosphoinositide 3-Kinase δ for the Treatment of Respiratory Disease

Kenneth Down, Augustin Amour, Angela M. Deakin et al. · Journal of Medicinal Chemistry · 2015 · 132 citations

Pharmacy, Medicinal Chemistry, Pharmacology +17

Discovery of 6-Amino-2-{[(1<i>S</i>)-1-methylbutyl]oxy}-9-[5-(1-piperidinyl)pentyl]-7,9-dihydro-8<i>H</i>-purin-8-one (GSK2245035), a Highly Potent and Selective Intranasal Toll-Like Receptor 7 Agonist for the Treatment of Asthma

Keith Biggadike, Mahbub Ahmed, D.I. Ball et al. · Journal of Medicinal Chemistry · 2016 · 40 citations

Life Sciences, Immunology, Pharmacology +14

Design and Development of a Macrocyclic Series Targeting Phosphoinositide 3-Kinase δ

Jonathan A. Spencer, Ian R. Baldwin, Nick Barton et al. · ACS Medicinal Chemistry Letters · 2020 · 12 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17