Donald M. Sperbeck

Microscale High-Throughput Experimentation as an Enabling Technology in Drug Discovery: Application in the Discovery of (Piperidinyl)pyridinyl-1 <i>H</i> -benzimidazole Diacylglycerol Acyltransferase 1 Inhibitors

Tim Cernak, Nathan J. Gesmundo, Kevin D. Dykstra et al. · Journal of Medicinal Chemistry · 2017 · 84 citations · Full text

Pharmacy, Chemistry, Pharmacology +11

Secondary Amides of (<i>R</i>)-3,3,3-Trifluoro-2-hydroxy-2-methylpropionic Acid as Inhibitors of Pyruvate Dehydrogenase Kinase

Thomas D. Aicher, Robert C. Anderson, Jiaping Gao et al. · Journal of Medicinal Chemistry · 1999 · 68 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +11

Ibrexafungerp: An orally active β-1,3-glucan synthesis inhibitor

James M. Apgar, Robert R. Wilkening, Dann L. Parker et al. · Bioorganic & Medicinal Chemistry Letters · 2020 · 50 citations

Medicine, Medicinal Chemistry, Pharmacology +4

(<i>R</i>)-3,3,3-Trifluoro-2-hydroxy-2-methylpropionamides Are Orally Active Inhibitors of Pyruvate Dehydrogenase Kinase

Thomas D. Aicher, Robert C. Anderson, Gregory R. Bebernitz et al. · Journal of Medicinal Chemistry · 1999 · 44 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +8

Discovery of MK-8831, A Novel Spiro-Proline Macrocycle as a Pan-Genotypic HCV-NS3/4a Protease Inhibitor

Santhosh Neelamkavil, Sony Agrawal, Thomas Bara et al. · ACS Medicinal Chemistry Letters · 2015 · 34 citations

Pharmacy, Medicinal Chemistry, Pharmacology +13