Rosita Lupi

Discovery of 2-[1-(4,4-Difluorocyclohexyl)piperidin-4-yl]-6-fluoro-3-oxo-2,3-dihydro-1<i>H</i>-isoindole-4-carboxamide (NMS-P118): A Potent, Orally Available, and Highly Selective PARP-1 Inhibitor for Cancer Therapy

Gianluca Papeo, Helena Posteri, Daniela Borghi et al. · Journal of Medicinal Chemistry · 2015 · 139 citations · Full text

Cancer Therapy, Drug Target, Pharmacotherapy +18

Crystal Structure of the T315I Abl Mutant in Complex with the Aurora Kinases Inhibitor PHA-739358

Michèle Modugno, Elena Casale, Chiara Soncini et al. · Cancer Research · 2007 · 132 citations · Full text

Hematological Malignancy, Tumor Biology, Kinase Domain +15

Endogenous ADP-ribosylation of the G Protein β Subunit Prevents the Inhibition of Type 1 Adenylyl Cyclase

Rosita Lupi, Daniela Corda, Maria Di Girolamo · Journal of Biological Chemistry · 2000 · 57 citations · Full text

Endogenous mono-ADP-ribosylation of the free Gβγ prevents stimulation of phosphoinositide 3-kinase-γ and phospholipase C-β2 and is activated by G-protein-coupled receptors

Rosita Lupi, Nadia Dani, Alexander Dietrich et al. · Biochemical Journal · 2002 · 32 citations · Full text

Betagamma Heterodimer, Cellular Physiology, Molecular Pharmacology +20

Identification of candidate substrates for poly(ADP‐ribose) polymerase‐2 (PARP2) in the absence of DNA damage using high‐density protein microarrays

Sonia Troiani, Rosita Lupi, Rita Perego et al. · FEBS Journal · 2011 · 29 citations · Full text

Dna Damage, Dna Microarrays, Molecular Biology +16