p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest

Vjekoslav Dulić, William K. Kaufmann, S J Wilson, +5

Cell

Radiation TherapyMedicineRadiation EffectRadiation ExposureP53-dependent Inhibition +7

High-throughput screening using patient-derived tumor xenografts to predict clinical trial drug response

Hui Gao, Joshua M. Korn, Stéphane Ferretti, +61

Nature Medicine

Tumor BiologyRadiologyOncologyCancer DetectionCancer Screening +8

Mammary hyperplasia and carcinoma in MMTV-cyclin D1 transgenic mice

Timothy C. Wang, Robert D. Cardiff, Lawrence Zukerberg, +3

Nature

Breast OncologyMammary GlandBreast CancerMedicineCell Biology +3

Association of human cyclin E with a periodic G1-S phase protein kinase

Vjekoslav Dulić, Emma Lees, Shawna C. O. Reed

Science

Human Cyclin EMolecular RegulationMolecular BiologyCell CycleTranscriptional Regulation +14

Project DRIVE: A Compendium of Cancer Dependencies and Synthetic Lethal Relationships Uncovered by Large-Scale, Deep RNAi Screening

E. Robert McDonald, Antoine de Weck, Michael R. Schlabach, +96

Cell

BioinformaticsTumor BiologyRadiation OncologyFunctional GenomicsProject Drive +11

Raf-Induced Proliferation or Cell Cycle Arrest Is Determined by the Level of Raf Activity with Arrest Mediated by p21^Cip1

Douglas Woods, David Parry, Holly Cherwinski, +3

Molecular and Cellular Biology

Cell ProliferationCell CycleRaf ActivityCancer BiologyTumor Biology +15

Dinaciclib (SCH 727965), a Novel and Potent Cyclin-Dependent Kinase Inhibitor

David Parry, Timothy J. Guzi, Nicole R. Davis, +14

Molecular Cancer Therapeutics

PharmacotherapyCancer BiologyTumor BiologyCdk9 ActivityReceptor Tyrosine Kinase +14

Disordered methionine metabolism in MTAP/CDKN2A-deleted cancers leads to dependence on PRMT5

Konstantinos J. Mavrakis, E. Robert McDonald, Michael R. Schlabach, +41

Science

Cyclin E/cdk2 and cyclin A/cdk2 kinases associate with p107 and E2F in a temporally distinct manner.

Emma Lees, Barbara Faha, Vjekoslav Dulić, +2

Genes & Development

Distinct MannerMolecular BiologyCell CycleTranscriptional RegulationSignaling Pathway +15

BRG1, a component of the SWI-SNF complex, is mutated in multiple human tumor cell lines.

Andrew Wong, Fergus Shanahan, Joseph C. Y. Chen, +16

PubMed

Cancer BiologyTumor BiologyTranscriptional RegulationCancer Cell BiologyRadiation Oncology +14