Amanda Balesano

Discovery of SARS-CoV-2 papain-like protease (PL ^pro ) inhibitors with efficacy in a murine infection model

Michelle R. Garnsey, Matthew C. Robinson, Luong T. Nguyen et al. · Science Advances · 2024 · 49 citations · Full text

Life Sciences, Infectious Diseases, Pharmacology +17

The Comparison of Machine Learning and Mechanistic In Vitro–In Vivo Extrapolation Models for the Prediction of Human Intrinsic Clearance

Christopher Keefer, George Chang, Li Di et al. · Molecular Pharmaceutics · 2023 · 26 citations

Pharmacy, Pharmacokinetics, Pharmacology +11

Defining the Selectivity of Chemical Inhibitors Used for Cytochrome P450 Reaction Phenotyping: Overcoming Selectivity Limitations with a Six-Parameter Inhibition Curve-Fitting Approach

Angela C. Doran, Woodrow Burchett, Connor Landers et al. · Drug Metabolism and Disposition · 2022 · 21 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +17

Discovery of First Branched-Chain Ketoacid Dehydrogenase Kinase (BDK) Inhibitor Clinical Candidate PF-07328948

Kevin J. Filipski, Luis Martinez-Alsina, Matthew R. Reese et al. · Journal of Medicinal Chemistry · 2024 · 12 citations

Pharmacy, Medicinal Chemistry, Pharmacology +13

An Improved Method for Cytochrome P450 Reaction Phenotyping Using a Sequential Qualitative-Then-Quantitative Approach

Angela C. Doran, Alyssa Dantonio, Gabrielle M. Gualtieri et al. · Drug Metabolism and Disposition · 2022 · 11 citations · Full text

Medicine, Biochemistry, Pharmacology +12