An oral SARS-CoV-2 M ^pro inhibitor clinical candidate for the treatment of COVID-19

Dafydd R. Owen, Charlotte Allerton, Annaliesa S. Anderson, +40

Science

Viral DiagnosticsWorldwide OutbreakImmunologyImmunotherapeuticsCovid-19 Epidemiology +14

Preclinical characterization of an intravenous coronavirus 3CL protease inhibitor for the potential treatment of COVID19

Britton Boras, Rhys Jones, Brandon J. Anson, +49

Nature Communications

Discovery of a Novel Inhibitor of Coronavirus 3CL Protease for the Potential Treatment of COVID-19

Britton Boras, Rhys Jones, Brandon J. Anson, +46

Sulfonamide Synthesis via Calcium Triflimide Activation of Sulfonyl Fluorides

Paramita Mukherjee, Cristian P. Woroch, Leah Cleary, +9

Organic Letters

Discovery of Brain-Penetrant, Irreversible Kynurenine Aminotransferase II Inhibitors for Schizophrenia

Amy B. Dounay, Marie Anderson, Bruce M. Bechle, +24

ACS Medicinal Chemistry Letters

Kat IiMedicinal ChemistryBiochemistryMedicineNatural Sciences +11

Ru/Ni Dual Catalytic Desulfinative Photoredox C_sp²–C_sp³ Cross-Coupling of Alkyl Sulfinate Salts and Aryl Halides

Thomas Knauber, Ramalakshmi Y. Chandrasekaran, Joseph W. Tucker, +5

Organic Letters

High‐Throughput Ligand Screening Enables the Enantioselective Conjugate Borylation of Cyclobutenones to Access Synthetically Versatile Tertiary Cyclobutylboronates

Helen A. Clement, Michele Boghi, Rory M. McDonald, +8

Angewandte Chemie International Edition

Bioorganic ChemistryOrganic ChemistryChemistryMedicinal ChemistryDiversity Oriented Synthesis +14

A Second-Generation Oral SARS-CoV-2 Main Protease Inhibitor Clinical Candidate for the Treatment of COVID-19

Charlotte Allerton, Joel T. Arcari, Lisa Aschenbrenner, +44

Journal of Medicinal Chemistry

Pyran-containing sulfonamide hydroxamic acids: potent MMP inhibitors that spare MMP-1

Lawrence A. Reiter, Ralph P. Robinson, Kim F. McClure, +18

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryPharmaceutical ScienceBiochemistryMedicineNatural Sciences +8

Discovery and Preclinical Characterization of 1-Methyl-3-(4-methylpyridin-3-yl)-6-(pyridin-2-ylmethoxy)-1 <i>H</i> -pyrazolo-[3,4- <i>b</i> ]pyrazine (PF470): A Highly Potent, Selective, and Efficacious Metabotropic Glutamate Receptor 5 (mGluR5) Negative Allosteric Modulator

Lei Zhang, Gayatri Balan, Gabriela Barreiro, +28

Journal of Medicinal Chemistry