Sofiya Yashchuk

Structure-based design, synthesis, X-ray studies, and biological evaluation of novel HIV-1 protease inhibitors containing isophthalamide-derived P2-ligands

Arun K. Ghosh, Jun Takayama, Luke A. Kassekert et al. · Bioorganic & Medicinal Chemistry Letters · 2015 · 40 citations · Full text

Combinatorial Chemistry, Medicinal Chemistry, Biochemistry +11

GRL-04810 and GRL-05010, Difluoride-Containing Nonpeptidic HIV-1 Protease Inhibitors (PIs) That Inhibit the Replication of Multi-PI-Resistant HIV-1 <i>In Vitro</i> and Possess Favorable Lipophilicity That May Allow Blood-Brain Barrier Penetration

Pedro Miguel Salcedo Gómez, Masayuki Amano, Sofiya Yashchuk et al. · Antimicrobial Agents and Chemotherapy · 2013 · 23 citations · Full text

Design of <i>gem</i>‐Difluoro‐<i>bis</i>‐Tetrahydrofuran as P2 Ligand for HIV‐1 Protease Inhibitors to Improve Brain Penetration: Synthesis, X‐ray Studies, and Biological Evaluation

Arun K. Ghosh, Sofiya Yashchuk, Akira Mizuno et al. · ChemMedChem · 2014 · 22 citations · Full text

Design of novel HIV-1 protease inhibitors incorporating isophthalamide-derived P2-P3 ligands: Synthesis, biological evaluation and X-ray structural studies of inhibitor-HIV-1 protease complex

Arun K. Ghosh, Margherita Brindisi, Prasanth R. Nyalapatla et al. · Bioorganic & Medicinal Chemistry · 2017 · 16 citations · Full text

X-ray Structural Studies, Biochemistry, Medicine +10

Potent Antiviral HIV-1 Protease Inhibitor GRL-02031 Adapts to the Structures of Drug Resistant Mutants with Its P1′-Pyrrolidinone Ring

Yu-Chung E. Chang, Xiaxia Yu, Ying Zhang et al. · Journal of Medicinal Chemistry · 2012 · 14 citations · Full text