A transcriptionally and functionally distinct PD-1+ CD8+ T cell pool with predictive potential in non-small-cell lung cancer treated with PD-1 blockade

Daniela S. Thommen, Viktor H. Koelzer, Petra Herzig, +16

Nature Medicine

Cancer ImmunosurveillanceNon-small-cell Lung CancerPd-1 BlockadeMedicineImmunology +6

Genome Sequence, Comparative Analysis, and Population Genetics of the Domestic Horse

Claire M. Wade, Elena Giulotto, Matteo Zoli, +54

Science

Dual angiopoietin-2 and VEGFA inhibition elicits antitumor immunity that is enhanced by PD-1 checkpoint blockade

Martina Schmittnaegel, Nicolò Rigamonti, Ece Kadioglu, +8

Science Translational Medicine

Efficacy, safety, and pharmacokinetics of emicizumab prophylaxis given every 4 weeks in people with haemophilia A (HAVEN 4): a multicentre, open-label, non-randomised phase 3 study

Steven W. Pipe, Midori Shima, Michaela Lehle, +14

The Lancet Haematology

Haven 4HematologyNon-randomised Phase 3Emicizumab ProphylaxisMedicine

DAP12/TREM2 Deficiency Results in Impaired Osteoclast Differentiation and Osteoporotic Features

Juha Paloneva, Jami Mandelin, Anna Kiialainen, +6

The Journal of Experimental Medicine

Suppression of microRNA activity amplifies IFN-γ-induced macrophage activation and promotes anti-tumour immunity

Caroline Baer, Mario Leonardo Squadrito, Damya Laoui, +7

Nature Cell Biology

Macrophage BiologyInflammationCytokineCancer ImmunosurveillanceIfn-γ-induced Macrophage Activation +11

Disease Modeling and Phenotypic Drug Screening for Diabetic Cardiomyopathy using Human Induced Pluripotent Stem Cells

Faye Drawnel, Stefano Boccardo, Michael Prummer, +23

Cell Reports

White-to-brown metabolic conversion of human adipocytes by JAK inhibition

Annie Moisan, Youn‐Kyoung Lee, Jitao David Zhang, +12

Nature Cell Biology

Circulating tumor <scp>DNA</scp> and circulating tumor cells in metastatic triple negative breast cancer patients

Jordan Madic, Anna Kiialainen, François‐Clément Bidard, +18

International Journal of Cancer

DNA methylation for subtype classification and prediction of treatment outcome in patients with childhood acute lymphoblastic leukemia

Lili Milani, Anders Lundmark, Anna Kiialainen, +10

Blood