Preclinical selection of a novel poly(ADP-ribose) polymerase inhibitor for clinical trial

Huw D. Thomas, Christopher Calabrese, Michael A. Batey, +9

Molecular Cancer Therapeutics

Novel Poly(ADP-ribose) Polymerase-1 Inhibitor, AG14361, Restores Sensitivity to Temozolomide in Mismatch Repair-Deficient Cells

Nicola J. Curtin, Lan-Zhen Wang, Anthie Yiakouvaki, +8

Clinical Cancer Research

Differences in the Conformational Energy Landscape of CDK1 and CDK2 Suggest a Mechanism for Achieving Selective CDK Inhibition

D.J. Wood, S. Korolchuk, Natalie J. Tatum, +4

Cell chemical biology

Signal TransductionSignaling PathwayNatural SciencesReceptor Tyrosine KinaseMolecular Biology +10

Novel Tricyclic Poly(ADP-ribose) Polymerase-1 Inhibitors with Potent Anticancer Chemopotentiating Activity:  Design, Synthesis, and X-ray Cocrystal Structure

Stacie S. Canan Koch, Lars Thoresen, Jayashree Tikhe, +22

Journal of Medicinal Chemistry

Pharmaceutical ScienceBioorganic ChemistryParp-1 ProteinChemical BiologyPolymerase-1 Inhibitors +16

N²-Substituted <i>O</i>⁶-Cyclohexylmethylguanine Derivatives:  Potent Inhibitors of Cyclin-Dependent Kinases 1 and 2

Ian R. Hardcastle, Christine E. Arris, Johanne Bentley, +15

Journal of Medicinal Chemistry

Identification of potent nontoxic poly(ADP-Ribose) polymerase-1 inhibitors: chemopotentiation and pharmacological studies.

Christopher Calabrese, Michael A. Batey, Huw D. Thomas, +12

PubMed

Pharmaceutical ScienceChemoprevention StrategyPharmacotherapyPolymerase-1 InhibitorsPotent Nontoxic Poly +17

Searching for Cyclin-Dependent Kinase Inhibitors Using a New Variant of the Cope Elimination

Roger J. Griffin, Andrew Henderson, Nicola J. Curtin, +7

Journal of the American Chemical Society

Combined PI3K and CDK2 inhibition induces cell death and enhances in vivo antitumour activity in colorectal cancer

Gary Beale, Emma J. Haagensen, Huw D. Thomas, +8

British Journal of Cancer

Design, Synthesis, and Evaluation of 3,4-Dihydro-2<i>H</i>-[1,4]diazepino[6,7,1-<i>hi</i>]indol-1-ones as Inhibitors of Poly(ADP-Ribose) Polymerase

Jayashree Tikhe, Stephen E. Webber, Zdeněk Hostomský, +17

Journal of Medicinal Chemistry

The CDK9 Tail Determines the Reaction Pathway of Positive Transcription Elongation Factor b

Sonja Baumli, Alison J. Hole, Lan-Zhen Wang, +2

Structure