Site-specific conjugation of a cytotoxic drug to an antibody improves the therapeutic index

Jagath R. Junutula, Helga Raab, Suzanna Clark, +28

Nature Biotechnology

Medicinal ChemistryImmunocytochemical TechniqueDrug TargetingTherapeutic IndexMedicine +8

A month–long effect from a single injection of microencapsulated human growth hormone

Olufunmi L. Johnson, Jeffrey L. Cleland, Hyejung Lee, +7

Nature Medicine

Growth HormoneHuman GrowthMedicineMicro-encapsulationSingle Injection +4

Monovalent antibody design and mechanism of action of onartuzumab, a MET antagonist with anti-tumor activity as a therapeutic agent

Mark Merchant, Xiaolei Ma, Henry R. Maun, +26

Proceedings of the National Academy of Sciences

Development of poly-(d,l-lactide–coglycolide) microsphere formulations containing recombinant human vascular endothelial growth factor to promote local angiogenesis

Jeffrey L. Cleland, Eileen Duenas, Ann Park, +4

Journal of Controlled Release

Tissue EngineeringRegenerative MedicineVascular Tissue EngineeringAngiogenesisEngineering +8

The Stabilization and Encapsulation of Human Growth Hormone into Biodegradable Microspheres

Olufunmi L. Johnson, Warren Jaworowicz, Jeffrey L. Cleland, +9

Pharmaceutical Research

Auristatin Antibody Drug Conjugate Physical Instability and the Role of Drug Payload

Yilma T. Adem, Kelly A. Schwarz, Eileen Duenas, +3

Bioconjugate Chemistry

Drug TargetImmunologyPharmacotherapyNanomedicineMedicinal Chemistry +16

Sustained release of recombinant human insulin-like growth factor-I for treatment of diabetes

Xanthe M. Lam, Eileen Duenas, Ann L. Daugherty, +1

Journal of Controlled Release

Regenerative MedicineSustained ReleaseTranslational MedicineGrowth HormoneInsulin Management +7

The Stability of Recombinant Human Growth Hormone in Poly(lactic-co-glycolic acid) (PLGA) Microspheres

Jeffrey L. Cleland, Anne Mac, Janet G. Yang, +7

Pharmaceutical Research

Intracranial Delivery of Recombinant Nerve Growth Factor: Release Kinetics and Protein Distribution for Three Delivery Systems

W. Mark Saltzman, Michele Mak, Melissa J. Mahoney, +2

Pharmaceutical Research

Encapsulation and stabilization of nerve growth factor into poly(lactic‐co‐glycolic) acid microspheres

Xanthe M. Lam, Eileen Duenas, Jeffrey L. Cleland

Journal of Pharmaceutical Sciences

Tissue EngineeringHydrogelsRegenerative MedicineBiofunctional MaterialEngineering +10