Mitochondrial Dynamics Controls T Cell Fate through Metabolic Programming

Michael D. Buck, David O’Sullivan, Ramon I. Klein Geltink, +16

Cell

Mitochondrial FunctionMitochondrial DynamicMetabolic ProgrammingMitochondrial DynamicsMetabolism +3

Multi-stage Differentiation Defines Melanoma Subtypes with Differential Vulnerability to Drug-Induced Iron-Dependent Oxidative Stress

Jennifer Tsoi, Lídia Robert, Kim H.T. Paraiso, +12

Cancer Cell

Tumor BiologyDifferential VulnerabilityPhotocarcinogenesisMelanomaDermatology +7

The metabolite α-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR

R Chin, Xudong Fu, Melody Y. Pai, +33

Nature

Lifespan ExtensionMetabolite α-Ketoglutarate ExtendsEnergy MetabolismMetabolic PathwaysBiochemistry +11

A Unifying Model for the Selective Regulation of Inducible Transcription by CpG Islands and Nucleosome Remodeling

Vladimir Ramirez-Carrozzi, Daniel Braas, Dev Bhatt, +7

Cell

ChromatinTranscriptional RegulationChromatin RemodelingNatural SciencesMolecular Biology +10

Asparagine promotes cancer cell proliferation through use as an amino acid exchange factor

Abigail S. Krall, Shili Xu, Thomas G. Graeber, +2

Nature Communications

Etomoxir Inhibits Macrophage Polarization by Disrupting CoA Homeostasis

Ajit S. Divakaruni, Wei Yuan Hsieh, Lucía Minarrieta, +18

Cell Metabolism

InflammationCytokineCoa HomeostasisImmunologyAutophagy +4

Nuclear Localization of Mitochondrial TCA Cycle Enzymes as a Critical Step in Mammalian Zygotic Genome Activation

Raghavendra Nagaraj, Mark S. Sharpley, Fangtao Chi, +5

Cell

ChromatinCritical StepMitochondrial BiogenesisMitochondrial FunctionNatural Sciences +7

R-2-hydroxyglutarate attenuates aerobic glycolysis in leukemia by targeting the FTO/m6A/PFKP/LDHB axis

Ying Qing, Lei Dong, Lei Gao, +26

Molecular Cell

BiochemistryMedicineCatabolismMetabolic RemodelingCarbonyl Metabolism +6

Lactate dehydrogenase activity drives hair follicle stem cell activation

Aimee Flores, John C. Schell, Abigail S. Krall, +14

Nature Cell Biology

Glycolytic Metabolism Plays a Functional Role in Regulating Human Pluripotent Stem Cell State

Wen Gu, Xavier Gaeta, Anna Sahakyan, +7

Cell stem cell

Induced Pluripotent Stem CellDevelopmental BiologyMedicineAdult Stem CellGlycolytic Metabolism +6