Olajumoke Adeniji-Popoola

A selective chemical probe for exploring the role of CDK8 and CDK19 in human disease

Trevor Dale, Paul A. Clarke, Christina Esdar et al. · Nature Chemical Biology · 2015 · 146 citations

Pharmacy, Medicinal Chemistry, Molecular Biology +11

Discovery of Potent, Selective, and Orally Bioavailable Small-Molecule Modulators of the Mediator Complex-Associated Kinases CDK8 and CDK19

Aurélie Mallinger, Kai Schiemann, Christian Rink et al. · Journal of Medicinal Chemistry · 2016 · 112 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +16

Assessing the mechanism and therapeutic potential of modulators of the human Mediator complex-associated protein kinases

Paul A. Clarke, Maria-Jesus Ortiz-Ruiz, Robert te Poele et al. · eLife · 2016 · 95 citations · Full text

Medicine, Oncology, Pharmacology +11

Discovery of Potent, Orally Bioavailable, Small-Molecule Inhibitors of WNT Signaling from a Cell-Based Pathway Screen

Aurélie Mallinger, Simon Crumpler, Mark Pichowicz et al. · Journal of Medicinal Chemistry · 2015 · 80 citations · Full text

Pharmacy, Medicinal Chemistry, Oncology +14

De Novo Missense Substitutions in the Gene Encoding CDK8, a Regulator of the Mediator Complex, Cause a Syndromic Developmental Disorder

Eduardo Calpena, Alexia Hervieu, Teresa Kaserer et al. · The American Journal of Human Genetics · 2019 · 63 citations · Full text

Life Sciences, Genetics, Molecular Genetics +17