VEGF Secreted by Hypoxic Müller Cells Induces MMP-2 Expression and Activity in Endothelial Cells to Promote Retinal Neovascularization in Proliferative Diabetic Retinopathy

Murilo Wendeborn Rodrigues, Xiaoban Xin, Kathleen Jee, +12

Diabetes

Ocular DiseaseEndothelial CellsMmp-2 ExpressionRetinal TherapiesOxidative Stress +18

Angiopoietin-like 4 is a potent angiogenic factor and a novel therapeutic target for patients with proliferative diabetic retinopathy

Savalan Babapoor-Farrokhran, Kathleen Jee, Brooks Puchner, +14

Proceedings of the National Academy of Sciences

Ocular DiseaseImmunologyAngiopoietin-like 4Retinal TherapiesDiabetic Retinopathy +19

Angiopoietin-like 4 binds neuropilins and cooperates with VEGF to induce diabetic macular edema

Akrit Sodhi, Tao Ma, Deepak Menon, +6

Journal of Clinical Investigation

Ocular DiseaseAngiopoietin-like 4Retinal Vascular LeakageDiabetic Macular EdemaRetinal Therapies +15

Autonomous bacterial localization and gene expression based on nearby cell receptor density

Hsuan‐Chen Wu, Chen‐Yu Tsao, David N. Quan, +10

Molecular Systems Biology

Expression of the angiogenic mediator, angiopoietin-like 4, in the eyes of patients with proliferative sickle retinopathy

Kathleen Jee, Murilo Wendeborn Rodrigues, Fabiana Kashiwabuchi, +7

PLoS ONE

Ocular DiseaseRetinal NeovascularizationImmunologyAngiopoietin-like 4Pathology +15

Expression Pattern of HIF-1α and VEGF Supports Circumferential Application of Scatter Laser for Proliferative Sickle Retinopathy

Murilo Wendeborn Rodrigues, Fabiana Kashiwabuchi, Monika Deshpande, +6

Investigative Ophthalmology & Visual Science

Targeting hypoxia-inducible factors with 32-134D safely and effectively treats diabetic eye disease in mice

Jing Zhang, Deepti Sharma, Aumreetam Dinabandhu, +16

Journal of Clinical Investigation

ANGPTL4 influences the therapeutic response of patients with neovascular age-related macular degeneration by promoting choroidal neovascularization

Qin Yu, Aumreetam Dinabandhu, Xuan Cao, +15

JCI Insight

Ocular DiseaseImmunologyTherapeutic ResponseChoroidal NeovascularizationRetinal Therapies +17

A Novel 3D Fibril Force Assay Implicates Src in Tumor Cell Force Generation in Collagen Networks

Robert J. Polackwich, Daniel Koch, Richard C. Arevalo, +6

PLoS ONE

Tissue EngineeringActive SrcEngineeringCell AdhesionBiofabrication +18

VEGF inhibition increases expression of HIF-regulated angiogenic genes by the RPE limiting the response of wet AMD eyes to aflibercept

Deepti Sharma, Evan Lau, Yu Qin, +11

Proceedings of the National Academy of Sciences