Samer Chmait

Antidiabetic effects of glucokinase regulatory protein small-molecule disruptors

David J. Lloyd, David J. St. Jean, Robert J. Kurzeja et al. · Nature · 2013 · 96 citations

Biochemistry, Medicine, Insulin Management +6

Discovery of potent, selective, and metabolically stable 4-(pyridin-3-yl)cinnolines as novel phosphodiesterase 10A (PDE10A) inhibitors

Essa Hu, Roxanne K. Kunz, Shannon Rumfelt et al. · Bioorganic & Medicinal Chemistry Letters · 2012 · 52 citations · Full text

Medicinal Chemistry, Novel Phosphodiesterase 10A, Biochemistry +10

Small Molecule Disruptors of the Glucokinase–Glucokinase Regulatory Protein Interaction: 3. Structure–Activity Relationships within the Aryl Carbinol Region of the <i>N</i>-Arylsulfonamido-<i>N</i>′-arylpiperazine Series

Nobuko Nishimura, Mark H. Norman, Longbin Liu et al. · Journal of Medicinal Chemistry · 2014 · 52 citations · Full text

Molecular Biology, Chemical Biology, Structure–activity Relationships +22

Design, Optimization, and Biological Evaluation of Novel Keto-Benzimidazoles as Potent and Selective Inhibitors of Phosphodiesterase 10A (PDE10A)

Essa Hu, Roxanne K. Kunz, Ning Chen et al. · Journal of Medicinal Chemistry · 2013 · 43 citations · Full text

Drug Target, Pharmacotherapy, Chemical Biology +17

Discovery and Structure-Guided Optimization of Diarylmethanesulfonamide Disrupters of Glucokinase–Glucokinase Regulatory Protein (GK–GKRP) Binding: Strategic Use of a N → S (n_N → σ*_S–X) Interaction for Conformational Constraint

Lewis D. Pennington, Michael D. Bartberger, Michael D. Croghan et al. · Journal of Medicinal Chemistry · 2015 · 38 citations · Full text

Molecular Biology, Peptide Science, Analytical Ultracentrifugation +22