Concepedia

Discovery of potent, selective, and metabolically stable 4-(pyridin-3-yl)cinnolines as novel phosphodiesterase 10A (PDE10A) inhibitors

Essa Hu, Roxanne K. Kunz, Shannon Rumfelt, Ning Chen, Roland W. Bürli, Chun Li, Kristin L. Andrews, Jiandong Zhang, Samer Chmait, Jeffrey H. Kogan,

Bioorganic & Medicinal Chemistry Letters · 2012 · 52 citations · 15 references

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References

15

Quantitative comparison of phosphodiesterase mRNA distribution in human brain and peripheral tissues

Viktor Lakics, Eric Karran, Frank Boess · Neuropharmacology · 2010 · 464 citations

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Isolation and characterization of a dual-substrate phosphodiesterase gene family: PDE10A

Scott H. Soderling, Sharon J. Bayuga, Joseph A. Beavo · Proceedings of the National Academy of Sciences · 1999 · 381 citations

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Preclinical Characterization of Selective Phosphodiesterase 10A Inhibitors: A New Therapeutic Approach to the Treatment of Schizophrenia

C J Schmidt, Douglas S. Chapin, J. Cianfrogna et al. · Journal of Pharmacology and Experimental Therapeutics · 2008 · 284 citations

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Distinct Roles of PDE4 and PDE10A in the Regulation of cAMP/PKA Signaling in the Striatum

Akinori Nishi, Mahomi Kuroiwa, Diane B. Miller et al. · Journal of Neuroscience · 2008 · 281 citations · Full text

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Genetic deletion of the striatum-enriched phosphodiesterase PDE10A: Evidence for altered striatal function

Judith A. Siuciak, Sheryl A. McCarthy, Douglas S. Chapin et al. · Neuropharmacology · 2006 · 230 citations

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