Hyperphosphorylated tau and neurofilament and cytoskeletal disruptions in mice overexpressing human p25, an activator of cdk5

Michael K. Ahlijanian, Nestor X. Barrezueta, Robert D. Williams, +9

Proceedings of the National Academy of Sciences

Molecular BiologyCell DeathCytoskeletonCellular PhysiologySocial Sciences +18

Preclinical Characterization of Selective Phosphodiesterase 10A Inhibitors: A New Therapeutic Approach to the Treatment of Schizophrenia

C J Schmidt, Douglas S. Chapin, J. Cianfrogna, +17

Journal of Pharmacology and Experimental Therapeutics

Inhibition of the striatum-enriched phosphodiesterase PDE10A: A novel approach to the treatment of psychosis

Judith A. Siuciak, Douglas S. Chapin, John F. Harms, +7

Neuropharmacology

NeuropsychologyPsychiatryPsychotic DisorderPsychotropic MedicationNovel Approach +11

Genetic deletion of the striatum-enriched phosphodiesterase PDE10A: Evidence for altered striatal function

Judith A. Siuciak, Sheryl A. McCarthy, Douglas S. Chapin, +8

Neuropharmacology

Altered Striatal FunctionAlzheimer's DiseaseMolecular NeuroscienceNeurochemical BiomarkersSocial Sciences +7

CP-809,101, a selective 5-HT2C agonist, shows activity in animal models of antipsychotic activity

Judith A. Siuciak, Douglas S. Chapin, Sheryl A. McCarthy, +8

Neuropharmacology

NeuropsychologyPsychoactive DrugPsychiatryMedicinePsychopharmacology +9

Behavioral and neurochemical characterization of mice deficient in the phosphodiesterase-4B (PDE4B) enzyme

Judith A. Siuciak, Sheryl A. McCarthy, Douglas S. Chapin, +1

Psychopharmacology

Molecular NeuroscienceBiochemistryNeurotransmitterMolecular BiologyMice Deficient +8

Antipsychotic profile of rolipram: efficacy in rats and reduced sensitivity in mice deficient in the phosphodiesterase-4B (PDE4B) enzyme

Judith A. Siuciak, Douglas S. Chapin, Sheryl A. McCarthy, +1

Psychopharmacology

Alzheimer's DiseaseReduced SensitivityPsychiatryMedicinePsychotropic Medication +6

Behavioral characterization of mice deficient in the phosphodiesterase-10A (PDE10A) enzyme on a C57/Bl6N congenic background

Judith A. Siuciak, Sheryl A. McCarthy, Douglas S. Chapin, +3

Neuropharmacology

Behavioral CharacterizationMolecular PhysiologySignal TransductionBiochemistryNatural Sciences +5

Disruption of the neurokinin-3 receptor (NK3) in mice leads to cognitive deficits

Judith A. Siuciak, Sheryl A. McCarthy, A. Martin, +6

Psychopharmacology

Mice LeadsMedicineImmunologyNeuropharmacologyBrain-immune Interaction +8

Behavioral and neurochemical characterization of mice deficient in the phosphodiesterase-1B (PDE1B) enzyme

Judith A. Siuciak, Sheryl A. McCarthy, Douglas S. Chapin, +3

Neuropharmacology

Molecular NeuroscienceBiochemistryNeurotransmitterMice DeficientNeurochemical Characterization +7