Concepedia

Brian A. Sparling

BA

Statistics

Publications

7

Citations

336

H-Index

7

Active since

2008

Affiliations

Amgen (United States)(Current)

Massachusetts Institute of Technology

Harvard University

Brian A. Sparling is an author at Amgen (United States) specializing in organic chemistry, engineering, and chemistry.

Top concepts

ChemistryEngineeringOrganic ChemistryPharmacologyNatural SciencesCatalysisBiomolecular EngineeringBiochemistryBiosynthesisPhotochemistry

Publications per year

2008–2019

7

Publications

7

Enantioselective Total Synthesis of Hyperforin

Brian A. Sparling, David C. Moebius, Matthew D. Shair · Journal of the American Chemical Society · 2012 · 114 citations

Asymmetric Catalysis, 18-Step Total Synthesis, Bioorganic Chemistry +15

Sulfonamides as Selective Na<sub>V</sub>1.7 Inhibitors: Optimizing Potency, Pharmacokinetics, and Metabolic Properties to Obtain Atropisomeric Quinolinone (AM-0466) that Affords Robust in Vivo Activity

Russell F. Graceffa, Alessandro A. Boezio, Jessica Able et al. · Journal of Medicinal Chemistry · 2017 · 66 citations · Full text

Decarboxylative Anti-Michael Addition to Olefins Mediated by Photoredox Catalysis

Gabrielle H. Lovett, Brian A. Sparling · Organic Letters · 2016 · 51 citations

Photoredox Catalysis, Engineering, Alkene Metathesis +12

Total Synthesis of (−)-Nemorosone and (+)-Secohyperforin

Brian A. Sparling, James K. Tucker, David C. Moebius et al. · Organic Letters · 2015 · 39 citations

Medicinal Chemistry, Biosynthesis, General Strategy +13

SmI<sub>2</sub>-Promoted Reformatsky-Type Coupling Reactions in Exceptionally Hindered Contexts

Brian A. Sparling, Ryan M. Moslin, Timothy F. Jamison · Organic Letters · 2008 · 35 citations · Full text

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