Journal of the American Chemical Society · 2012 · 114 citations · 63 references
Asymmetric Catalysis18-Step Total SynthesisBioorganic ChemistryEngineeringHeterocyclicAlkene MetathesisLatent Symmetry ElementsNatural SciencesOrganic ChemistryCatalysisEnantioselective Total SynthesisChemistryHeterocycle ChemistryKey Quaternary StereocentersPharmacologyStereoselective SynthesisEnantioselective SynthesisBiomolecular Engineering
A modular, 18-step total synthesis of hyperforin is described. The natural product was quickly accessed using latent symmetry elements, whereby a group-selective, Lewis acid-catalyzed epoxide-opening cascade cyclization was used to furnish the bicyclo[3.3.1]nonane core and set two key quaternary stereocenters.
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St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor
Linda B. Moore, Bryan Goodwin, Stacey A. Jones et al. · Proceedings of the National Academy of Sciences · 2000 · 936 citations · Full text
Pharmacotherapy, Oxidative Stress, Gastrointestinal Peptide Hormone +21