Single-Cell RNA Sequencing Reveals Stromal Evolution into LRRC15+ Myofibroblasts as a Determinant of Patient Response to Cancer Immunotherapy

Claudia X. Dominguez, Sören Müller, Shilpa Keerthivasan, +14

Cancer Discovery

A comprehensive transcriptional portrait of human cancer cell lines

Christiaan Klijn, Steffen Durinck, Eric Stawiski, +27

Nature Biotechnology

Tumor BiologyMedicineCancer GenomicsComprehensive Transcriptional PortraitSystems Biology +4

USP7 small-molecule inhibitors interfere with ubiquitin binding

Lorna Kategaya, Paola Di Lello, Lionel Rougé, +41

Nature

Molecular DockingUbiquitin BindingDrug TargetMedicineNatural Sciences +5

BRCA1 RING Function Is Essential for Tumor Suppression but Dispensable for Therapy Resistance

Rinske Drost, Peter Bouwman, Sven Rottenberg, +13

Cancer Cell

Tumor BiologyOncologyMedicineTumor SuppressionTumor Suppressor +8

A resource for cell line authentication, annotation and quality control

Mamie Yu, Suresh Selvaraj, May M.Y. Liang-Chu, +9

Nature

Mobile SecurityEngineeringData ScienceInformation SecurityBiometrics +9

A transcriptional MAPK Pathway Activity Score (MPAS) is a clinically relevant biomarker in multiple cancer types

Marie-Claire Wagle, Daniel C. Kirouac, Christiaan Klijn, +20

npj Precision Oncology

Recurrent Loss of NFE2L2 Exon 2 Is a Mechanism for Nrf2 Pathway Activation in Human Cancers

Leonard D. Goldstein, James Lee, Florian Gnad, +12

Cell Reports

Genome and transcriptome sequencing of lung cancers reveal diverse mutational and splicing events

Jinfeng Liu, William Lee, Zhaoshi Jiang, +31

Genome Research

EngineeringGeneticsAdditional ExonGenomicsSplicing Variant +18

BRCA1185delAG tumors may acquire therapy resistance through expression of RING-less BRCA1

Rinske Drost, Kiranjit K. Dhillon, Hanneke van der Gulden, +26

Journal of Clinical Investigation

Breast OncologyBrca1185stop MutationsBrca1 ProteinPathologyBreast Cancer 1 +16

ARAF mutations confer resistance to the RAF inhibitor belvarafenib in melanoma

Ivana Yen, Jeeyun Lee, Yong Sang Hong, +35

Nature

Raf Inhibitor BelvarafenibMelanomaPathologyMolecular OncologyCancer Genetics +4