Neoantigen vaccine generates intratumoral T cell responses in phase Ib glioblastoma trial

Derin B. Keskin, Annabelle Anandappa, Jing Sun, +48

Nature

Neuro-oncologyTumor ImmunologyCancer ImmunosurveillanceGliomaImmunology +8

Developmental and oncogenic programs in H3K27M gliomas dissected by single-cell RNA-seq

Mariella G. Filbin, Itay Tirosh, Volker Hovestadt, +46

Science

Gut microbiome–derived metabolites modulate intestinal epithelial cell damage and mitigate graft-versus-host disease

Nathan D. Mathewson, Robert R. Jenq, Anna V. Mathew, +18

Nature Immunology

InflammationMicrobiota FunctionGraft-versus-host DiseaseMucosal ImmunologyDysbiosis +8

Interactions between cancer cells and immune cells drive transitions to mesenchymal-like states in glioblastoma

Toshiro Hara, Rony Chanoch-Myers, Nathan D. Mathewson, +18

Cancer Cell

Neuro-oncologyMesenchymal-like StatesCancer ImmunosurveillanceMedicineImmunology +9

Inhibitory CD161 receptor identified in glioma-infiltrating T cells by single-cell analysis

Nathan D. Mathewson, Orr Ashenberg, Itay Tirosh, +37

Cell

Neuro-oncologyCancer ImmunosurveillanceGliomaMedicineInhibitory Cd161 Receptor +7

Integrin αvβ6–TGFβ–SOX4 Pathway Drives Immune Evasion in Triple-Negative Breast Cancer

Archis Bagati, Sushil Kumar, Peng Jiang, +13

Cancer Cell

Breast OncologyCancer ImmunosurveillanceMedicineImmune RegulationTumor Immunity +7

Single-Cell RNA-Seq Reveals Cellular Hierarchies and Impaired Developmental Trajectories in Pediatric Ependymoma

Johannes Gojo, Bernhard Englinger, Li Jiang, +38

Cancer Cell

Cell LineageDevelopmental BiologySingle Cell SequencingMedicineSingle-cell Genomics +8

Opposing immune and genetic mechanisms shape oncogenic programs in synovial sarcoma

Livnat Jerby‐Arnon, Cyril Neftel, Marni E. Shore, +47

Nature Medicine

Cancer ImmunosurveillanceSynovial SarcomaImmunologyImmunoeditingImmunologic Mechanism +5

CARM1 Inhibition Enables Immunotherapy of Resistant Tumors by Dual Action on Tumor Cells and T Cells

Sushil Kumar, Zexian Zeng, Archis Bagati, +19

Cancer Discovery

Siglec-G–CD24 axis controls the severity of graft-versus-host disease in mice

Tomomi Toubai, Guoqing Hou, Nathan D. Mathewson, +12

Blood