An immunogenic personal neoantigen vaccine for patients with melanoma

Patrick A. Ott, Zhuting Hu, Derin B. Keskin, +37

Nature

VaccinationTumor ImmunologyMelanomaImmunologyTherapeutic Vaccine +3

Neoantigen vaccine generates intratumoral T cell responses in phase Ib glioblastoma trial

Derin B. Keskin, Annabelle Anandappa, Jing Sun, +48

Nature

Neuro-oncologyTumor ImmunologyCancer ImmunosurveillanceGliomaImmunology +8

Personal neoantigen vaccines induce persistent memory T cell responses and epitope spreading in patients with melanoma

Zhuting Hu, Donna Leet, Rosa Lundbye Allesøe, +38

Nature Medicine

VaccinationTumor ImmunologyEpitope SpreadingCancer ImmunosurveillancePersonal Neoantigen Vaccines +9

Allelic dilution obscures detection of a biologically significant resistance mutation in EGFR-amplified lung cancer

J. A. Engelman, Toru Mukohara, Kreshnik Zejnullahu, +13

Journal of Clinical Investigation

EngineeringEgfr-amplified Lung CancerPathologyCancer BiologyTumor Biology +18

Mitochondrial Reprogramming Underlies Resistance to BCL-2 Inhibition in Lymphoid Malignancies

Romain Guièze, Vivian M. Liu, Daniel Rosebrock, +38

Cancer Cell

Lymphoid NeoplasiaMitochondrial FunctionMedicineMalignant Blood DisorderImmunology +7

L-3-n-Butylphthalide Improves Cognitive Impairment and Reduces Amyloid-  in a Transgenic Model of Alzheimer's Disease

Ying Peng, Jing Sun, Stephanie Hon, +5

Journal of Neuroscience

Phosphatidylinositol 3-kinase δ blockade increases genomic instability in B cells

Mara Compagno, Qi Wang, Chiara Pighi, +17

Nature

Signal TransductionSignaling PathwayCell RegulationImmunologyB Cells +3

Growth dynamics in naturally progressing chronic lymphocytic leukaemia

Michaela Gruber, Ivana Božić, Ignaty Leshchiner, +24

Nature

Lymphoid NeoplasiaMalignant Blood DisorderHematologyImmunologyGrowth Dynamics +4

A Murine Model of Chronic Lymphocytic Leukemia Based on B Cell-Restricted Expression of Sf3b1 Mutation and Atm Deletion

Shanye Yin, Rutendo Gambe, Jing Sun, +26

Cancer Cell

A cloning and expression system to probe T-cell receptor specificity and assess functional avidity to neoantigens

Zhuting Hu, Annabelle Anandappa, Jing Sun, +23

Blood