Cynthia Kim

Prodrugs of a 1′-CN-4-Aza-7,9-dideazaadenosine <i>C</i>-Nucleoside Leading to the Discovery of Remdesivir (GS-5734) as a Potent Inhibitor of Respiratory Syncytial Virus with Efficacy in the African Green Monkey Model of RSV

Richard L. Mackman, Hon C. Hui, Michel Perron et al. · Journal of Medicinal Chemistry · 2021 · 79 citations · Full text

Key Metabolic Enzymes Involved in Remdesivir Activation in Human Lung Cells

Ruidong Li, Albert Liclican, Yili Xu et al. · Antimicrobial Agents and Chemotherapy · 2021 · 61 citations · Full text

Off-Target <i>In Vitro</i> Profiling Demonstrates that Remdesivir Is a Highly Selective Antiviral Agent

Yili Xu, Ona Barauskas, Cynthia Kim et al. · Antimicrobial Agents and Chemotherapy · 2020 · 57 citations · Full text

Inhaled remdesivir reduces viral burden in a nonhuman primate model of SARS-CoV-2 infection

Meghan S. Vermillion, Eisuke Murakami, Bin Ma et al. · Science Translational Medicine · 2021 · 42 citations · Full text

Viral Pathogenesis, Immunology, Pharmacotherapy +16

Species differences in liver accumulation and metabolism of nucleotide prodrug sofosbuvir

Ting Wang, Darius Babusis, Yeojin Park et al. · Drug Metabolism and Pharmacokinetics · 2020 · 16 citations

Hepatology, Health Sciences, Medicine +14