Shawn S. Chang

LLY-507, a Cell-active, Potent, and Selective Inhibitor of Protein-lysine Methyltransferase SMYD2

Hannah Nguyen, Abdellah Allali‐Hassani, Stephen Antonysamy et al. · Journal of Biological Chemistry · 2015 · 131 citations · Full text

Life Sciences, Medicinal Chemistry, Molecular Biology +11

Crystal Structures of mPGES-1 Inhibitor Complexes Form a Basis for the Rational Design of Potent Analgesic and Anti-Inflammatory Therapeutics

J.G. Luz, Stephen Antonysamy, Steven L. Kuklish et al. · Journal of Medicinal Chemistry · 2015 · 65 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +14

Computational stabilization of T cell receptors allows pairing with antibodies to form bispecifics

Karen Froning, Jack B. Maguire, Arlene Sereno et al. · Nature Communications · 2020 · 38 citations · Full text

Life Sciences, Immunology, Molecular Biology +17

A structure-based engineering approach to abrogate pre-existing antibody binding to biotherapeutics

Joanne Lin, Stacey L. Lee, Anna M. Russell et al. · PLoS ONE · 2021 · 19 citations · Full text

Pharmacy, Immunology, Pharmacology +17

Functional Annotation and Structural Characterization of a Novel Lactonase Hydrolyzing <scp>d</scp>-Xylono-1,4-lactone-5-phosphate and <scp>l</scp>-Arabino-1,4-lactone-5-phosphate

Magdalena Korczynska, Dao Feng Xiang, Zhening Zhang et al. · Biochemistry · 2014 · 14 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17