Venice Du Pont

Remdesivir Inhibits SARS-CoV-2 in Human Lung Cells and Chimeric SARS-CoV Expressing the SARS-CoV-2 RNA Polymerase in Mice

Andrea J. Pruijssers, Amelia S. George, Alexandra Schäfer et al. · Cell Reports · 2020 · 530 citations · Full text

Prodrugs of a 1′-CN-4-Aza-7,9-dideazaadenosine <i>C</i>-Nucleoside Leading to the Discovery of Remdesivir (GS-5734) as a Potent Inhibitor of Respiratory Syncytial Virus with Efficacy in the African Green Monkey Model of RSV

Richard L. Mackman, Hon C. Hui, Michel Perron et al. · Journal of Medicinal Chemistry · 2021 · 79 citations · Full text

Therapeutic treatment with an oral prodrug of the remdesivir parental nucleoside is protective against SARS-CoV-2 pathogenesis in mice

Alexandra Schäfer, David R. Martinez, John J. Won et al. · Science Translational Medicine · 2022 · 77 citations · Full text

Immunology, Immunotherapeutics, Innate Immunity +20

Remdesivir and GS-441524 Retain Antiviral Activity against Delta, Omicron, and Other Emergent SARS-CoV-2 Variants

Jared Pitts, Jiani Li, Jason K. Perry et al. · Antimicrobial Agents and Chemotherapy · 2022 · 74 citations · Full text

Discovery of GS-5245 (Obeldesivir), an Oral Prodrug of Nucleoside GS-441524 That Exhibits Antiviral Efficacy in SARS-CoV-2-Infected African Green Monkeys

Richard L. Mackman, Rao Kalla, Darius Babusis et al. · Journal of Medicinal Chemistry · 2023 · 53 citations · Full text