Jason Halladay

GDC-0449—A potent inhibitor of the hedgehog pathway

Kirk Robarge, Shirley A. Brunton, Georgette M. Castanedo et al. · Bioorganic & Medicinal Chemistry Letters · 2009 · 385 citations · Full text

Molecular Pharmacology, Signaling Pathway, Molecular Pathway +6

Discovery of a Potent Small-Molecule Antagonist of Inhibitor of Apoptosis (IAP) Proteins and Clinical Candidate for the Treatment of Cancer (GDC-0152)

John A. Flygare, Maureen H. Beresini, Nageshwar Budha et al. · Journal of Medicinal Chemistry · 2012 · 247 citations · Full text

Apoptosis, Cell Death, Clinical Candidate +20

Lead identification of novel and selective TYK2 inhibitors

Jun Liang, Vickie Tsui, Anne van Abbema et al. · European Journal of Medicinal Chemistry · 2013 · 122 citations · Full text

Medicinal Chemistry, Hit Identification, Biochemistry +6

Discovery of Highly Potent, Selective, and Brain-Penetrant Aminopyrazole Leucine-Rich Repeat Kinase 2 (LRRK2) Small Molecule Inhibitors

Anthony A. Estrada, Bryan Chan, Charles Baker‐Glenn et al. · Journal of Medicinal Chemistry · 2013 · 121 citations · Full text

Lead Optimization of a 4-Aminopyridine Benzamide Scaffold To Identify Potent, Selective, and Orally Bioavailable TYK2 Inhibitors

Jun Liang, Anne van Abbema, Mercedesz Balázs et al. · Journal of Medicinal Chemistry · 2013 · 97 citations · Full text

Pharmaceutical Research, Immunology, Lead Identification +24