CD8+ T-cell responses to adeno-associated virus capsid in humans

Federico Mingozzi, Marcela V. Maus, Daniel J. Hui, +10

Nature Medicine

Cd8+ T-cell ResponsesImmunologyAntiviral ResponseVirologyCd4 T Cell Responses +3

In vivo genome editing restores haemostasis in a mouse model of haemophilia

Hojun Li, Virginia Haurigot, Yannick Doyon, +17

Nature

Vivo GenomeKnockout MouseEngineeringGenome SurgeryGenetics +10

Platelet- and megakaryocyte-derived microparticles transfer CXCR4 receptor to CXCR4-null cells and make them susceptible to infection by X4-HIV

Tomasz Rozmysłowicz, Marcin Majka, Jacek Kijowski, +6

AIDS

Capsid antigen presentation flags human hepatocytes for destruction after transduction by adeno-associated viral vectors

Gary C. Pien, Etiena Basner‐Tschakarjan, Daniel J. Hui, +8

Journal of Clinical Investigation

Adeno-associated VirusAdeno-associated Viral VectorsViral ReplicationHepatologyViral Hepatitis +12

Pre-existing AAV Capsid-specific CD8+ T Cells are Unable to Eliminate AAV-transduced Hepatocytes

Hua Li, Samuel L. Murphy, Wynetta Giles‐Davis, +6

Molecular Therapy

Pharmacological Modulation of Humoral Immunity in a Nonhuman Primate Model of AAV Gene Transfer for Hemophilia B

Federico Mingozzi, Yifeng Chen, Samuel L. Murphy, +9

Molecular Therapy

Diverse IgG subclass responses to adeno‐associated virus infection and vector administration

Samuel L. Murphy, Hojun Li, Federico Mingozzi, +4

Journal of Medical Virology

Undetectable Transcription of cap in a Clinical AAV Vector: Implications for Preformed Capsid in Immune Responses

Bernd Hauck, Samuel L. Murphy, Peter H. Smith, +7

Molecular Therapy

Prolonged Susceptibility to Antibody-mediated Neutralization for Adeno-associated Vectors Targeted to the Liver

Samuel L. Murphy, Hojun Li, Shangzhen Zhou, +2

Molecular Therapy

ImmunologyCell CultureImmunotherapyClearance KineticsHepatotoxicity +17

Bone marrow CD34+ cells and megakaryoblasts secrete β-chemokines that block infection of hematopoietic cells by M-tropic R5 HIV

Marcin Majka, Tomasz Rozmysłowicz, Benhur Lee, +5

Journal of Clinical Investigation