Alva M. Casey

Macrophage fumarate hydratase restrains mtRNA-mediated interferon production

Alexander Hooftman, Christian G. Peace, Dylan G. Ryan et al. · Nature · 2023 · 201 citations · Full text

Macrophage Fumarate Hydratase, Rna Biology, Gene Expression +3

Mitochondrial complex I activity in microglia sustains neuroinflammation

Luca Peruzzotti‐Jametti, Carolyn M. Willis, Grzegorz Krzak et al. · Nature · 2024 · 169 citations · Full text

Nrf2 activation reprograms macrophage intermediary metabolism and suppresses the type I interferon response

Dylan G. Ryan, Elena V. Knatko, Alva M. Casey et al. · iScience · 2022 · 99 citations · Full text

Inflammation, Cytokine, Host Response +12

Pro-inflammatory macrophages produce mitochondria-derived superoxide by reverse electron transport at complex I that regulates IL-1β release during NLRP3 inflammasome activation

Alva M. Casey, Dylan G. Ryan, Hiran A. Prag et al. · Nature Metabolism · 2025 · 58 citations · Full text

Ergothioneine improves healthspan of aged animals by enhancing cGPDH activity through CSE-dependent persulfidation

Dunja Petrovic, Luke Slade, Yiorgos Paikopoulos et al. · Cell Metabolism · 2025 · 32 citations · Full text

Aging, Medicine, Lipid Peroxidation +7