Tanya Jewell

Discovery of (<i>R</i>)-6-Cyclopentyl-6-(2-(2,6-diethylpyridin-4-yl)ethyl)-3-((5,7-dimethyl-[1,2,4]triazolo[1,5-<i>a</i>]pyrimidin-2-yl)methyl)-4-hydroxy-5,6-dihydropyran-2-one (PF-00868554) as a Potent and Orally Available Hepatitis C Virus Polymerase Inhibitor

Hui Li, John Tatlock, Angelica Linton et al. · Journal of Medicinal Chemistry · 2009 · 119 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Identification and structure-based optimization of novel dihydropyrones as potent HCV RNA polymerase inhibitors

Hui Li, John Tatlock, Angelica Linton et al. · Bioorganic & Medicinal Chemistry Letters · 2006 · 54 citations · Full text

Pharmacy, Medicinal Chemistry, Molecular Biology +16

Optimization of Potent, Selective, and Orally Bioavailable Pyrrolodinopyrimidine-Containing Inhibitors of Heat Shock Protein 90. Identification of Development Candidate 2-Amino-4-{4-chloro-2-[2-(4-fluoro-1<i>H</i>-pyrazol-1-yl)ethoxy]-6-methylphenyl}-<i>N</i>-(2,2-difluoropropyl)-5,7-dihydro-6<i>H</i>-pyrrolo[3,4-<i>d</i>]pyrimidine-6-carboxamide

Luke R. Zehnder, Michael J. Bennett, Jerry Meng et al. · Journal of Medicinal Chemistry · 2011 · 42 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Allosteric Inhibitors of Hepatitis C Polymerase:  Discovery of Potent and Orally Bioavailable Carbon-Linked Dihydropyrones

Hui Li, Angelica Linton, John Tatlock et al. · Journal of Medicinal Chemistry · 2007 · 33 citations

Pharmacy, Medicinal Chemistry, Pharmacology +17

Preparation of immobilized swainsonine analogs on solid support

William H. Pearson, Luyi Guo, Tanya Jewell · Tetrahedron Letters · 2002 · 10 citations

Natural Sciences, Pharmaceutics, Biomaterials +7