Nicolas Proisy

Inhibition of Hsp90 with Synthetic Macrolactones: Synthesis and Structural and Biological Evaluation of Ring and Conformational Analogs of Radicicol

Nicolas Proisy, Swee Y. Sharp, Kathy Boxall et al. · Chemistry & Biology · 2006 · 66 citations · Full text

Combinatorial Chemistry, Medicinal Chemistry, Pharmaceutical Chemistry +12

Structure-Guided Evolution of Potent and Selective CHK1 Inhibitors through Scaffold Morphing

John Reader, Thomas P. Matthews, Suki Klair et al. · Journal of Medicinal Chemistry · 2011 · 59 citations · Full text

Combinatorial Chemistry, Drug Target, Bioorganic Chemistry +18

Multiparameter Lead Optimization to Give an Oral Checkpoint Kinase 1 (CHK1) Inhibitor Clinical Candidate: (<i>R</i>)-5-((4-((Morpholin-2-ylmethyl)amino)-5-(trifluoromethyl)pyridin-2-yl)amino)pyrazine-2-carbonitrile (CCT245737)

James Osborne, Thomas P. Matthews, Tatiana McHardy et al. · Journal of Medicinal Chemistry · 2016 · 36 citations · Full text

Synthetic ansamycins prepared by a ring-expanding Claisen rearrangement. Synthesis and biological evaluation of ring and conformational analogues of the Hsp90 molecular chaperone inhibitor geldanamycin

Christopher S. P. McErlean, Nicolas Proisy, Christopher J. Davis et al. · Organic & Biomolecular Chemistry · 2007 · 21 citations