HOIP Deficiency Causes Embryonic Lethality by Aberrant TNFR1-Mediated Endothelial Cell Death

Nieves Peltzer, Eva Rieser, Lucia Taraborrelli, +11

Cell Reports

Molecular RegulationApoptosisImmune RegulationImmunologyPathology +18

TNFR1-dependent cell death drives inflammation in Sharpin-deficient mice

James Rickard, Holly Anderton, Nima Etemadi, +20

eLife

ApoptosisImmunologyImmune RegulationCell DeathImmunologic Mechanism +14

Mitochondrial permeabilization engages NF-κB-dependent anti-tumour activity under caspase deficiency

Evangelos Giampazolias, Barbara Zunino, Sandeep Dhayade, +24

Nature Cell Biology

Tumor BiologyMitochondrial FunctionCell DeathMitochondrial PermeabilizationMedicine +2

LUBAC is essential for embryogenesis by preventing cell death and enabling haematopoiesis

Nieves Peltzer, Maurice Darding, Antonella Montinaro, +24

Nature

Developmental BiologyCell DivisionCell DeathCell ProliferationCell Fate Determination +3

LUBAC prevents lethal dermatitis by inhibiting cell death induced by TNF, TRAIL and CD95L

Lucia Taraborrelli, Nieves Peltzer, Antonella Montinaro, +17

Nature Communications

LUBAC deficiency perturbs TLR3 signaling to cause immunodeficiency and autoinflammation

Julia Zinngrebe, Eva Rieser, Lucia Taraborrelli, +13

The Journal of Experimental Medicine

Caspase-3 Protects Stressed Organs against Cell Death

Hadi Khalil, Nieves Peltzer, Joël Walicki, +8

Molecular and Cellular Biology

ApoptosisImmunologyStress Intensity SensorCell DeathCellular Physiology +15

RIPK1 and Caspase-8 Ensure Chromosome Stability Independently of Their Role in Cell Death and Inflammation

Gianmaria Liccardi, Laura Ramos Garcia, Tencho Tenev, +22

Molecular Cell

The Linear ubiquitin chain assembly complex acts as a liver tumor suppressor and inhibits hepatocyte apoptosis and hepatitis

Yutaka Shimizu, Nieves Peltzer, Alexandra Sevko, +4

Hepatology

Biallelic human SHARPIN loss of function induces autoinflammation and immunodeficiency

Hirotsugu Oda, Kalpana Manthiram, Pallavi Pimpale Chavan, +59

Nature Immunology

InflammationPrimary ImmunodeficiencyAutoimmune DiseaseFunction Induces AutoinflammationImmunodeficiencies +10