Linear ubiquitination prevents inflammation and regulates immune signalling

Björn Gerlach, Stefanie M. Cordier, Anna C. Schmukle, +13

Nature

InflammationImmunologyImmune RegulationAutoimmunityImmune Mediator +3

TNFR1-dependent cell death drives inflammation in Sharpin-deficient mice

James Rickard, Holly Anderton, Nima Etemadi, +20

eLife

ApoptosisImmunologyImmune RegulationCell DeathImmunologic Mechanism +14

LUBAC is essential for embryogenesis by preventing cell death and enabling haematopoiesis

Nieves Peltzer, Maurice Darding, Antonella Montinaro, +24

Nature

Developmental BiologyCell DivisionCell DeathCell ProliferationCell Fate Determination +3

In TNF-stimulated Cells, RIPK1 Promotes Cell Survival by Stabilizing TRAF2 and cIAP1, which Limits Induction of Non-canonical NF-κB and Activation of Caspase-8

Ian E. Gentle, W. Wei‐Lynn Wong, Joseph M. Evans, +10

Journal of Biological Chemistry

TRAF2 regulates TNF and NF-κB signalling to suppress apoptosis and skin inflammation independently of Sphingosine kinase 1

Nima Etemadi, Michaël Chopin, Holly Anderton, +17

eLife

Adaptive Immune SystemImmunologyImmune RegulationCell DeathInnate Immunity +23

A missense mutation in the MLKL brace region promotes lethal neonatal inflammation and hematopoietic dysfunction

Joanne M. Hildebrand, Maria Kauppi, Ian J. Majewski, +67

Nature Communications

RIPK1 prevents TRADD-driven, but TNFR1 independent, apoptosis during development

Holly Anderton, Esther Bandala‐Sanchez, Daniel S. Simpson, +8

Cell Death and Differentiation

Cell RegulationApoptosisImmunologyCell DeathRipk1 Prevents +3

Combination of IAP antagonist and IFNγ activates novel caspase-10- and RIPK1-dependent cell death pathways

Maria C. Tanzer, Nufail Khan, James Rickard, +15

Cell Death and Differentiation

InflammationMolecular ImmunologySignal TransductionMedicineApoptosis +8

Inhibitor of Apoptosis Proteins (IAPs) Limit RIPK1-Mediated Skin Inflammation

Holly Anderton, James Rickard, George A. Varigos, +2

Journal of Investigative Dermatology

InflammationAutoimmune DiseaseCutaneous BiologyApoptosisImmunology +7

An immunohistochemical atlas of necroptotic pathway expression

Shene Chiou, Aysha Al‐Ani, Yi Pan, +36

EMBO Molecular Medicine

InflammationAutoimmune DiseaseApoptosisImmunologyCell Death +8