Combinatorial therapy with BAR502 and UDCA resets FXR and GPBAR1 signaling and reverses liver histopathology in a model of NASH

Silvia Marchianò, Michele Biagioli, Elva Morretta, +10

Scientific Reports

ImmunologyPathologyFatty Liver DiseaseBile Acid ContentMetabolic Syndrome +22

Activation of GPBAR1 attenuates vascular inflammation and atherosclerosis in a mouse model of NAFLD-related cardiovascular disease

Michele Biagioli, Silvia Marchianò, Cristina Di Giorgio, +20

Biochemical Pharmacology

Microbial-derived bile acid reverses inflammation in IBD via GPBAR1 agonism and RORγt inverse agonism

Michele Biagioli, Cristina Di Giorgio, Carmen Massa, +20

Biomedicine & Pharmacotherapy

Discovery of BAR502, as potent steroidal antagonist of leukemia inhibitory factor receptor for the treatment of pancreatic adenocarcinoma

Cristina Di Giorgio, Rachele Bellini, Antonio Lupia, +16

Frontiers in Oncology

Defective Bile Acid Signaling Promotes Vascular Dysfunction, Supporting a Role for G‐Protein Bile Acid Receptor 1/Farnesoid X Receptor Agonism and Statins in the Treatment of Nonalcoholic Fatty Liver Disease

Silvia Marchianò, Michele Biagioli, Martina Bordoni, +18

Journal of the American Heart Association

Repositioning Mifepristone as a Leukaemia Inhibitory Factor Receptor Antagonist for the Treatment of Pancreatic Adenocarcinoma

Cristina Di Giorgio, Antonio Lupia, Silvia Marchianò, +14

Cells

OncologyPotent Lifr AntagonistPancreatic CancerMedicineImmunology +12

The leukemia inhibitory factor regulates fibroblast growth factor receptor 4 transcription in gastric cancer

Cristina Di Giorgio, Rachele Bellini, Antonio Lupia, +21

Cellular Oncology

Bile acids serve as endogenous antagonists of the Leukemia inhibitory factor (LIF) receptor in oncogenesis

Cristina Di Giorgio, Elva Morretta, Antonio Lupia, +19

Biochemical Pharmacology

Chemoprevention StrategyImmunologyPathologyCholangiopathiesCancer Biology +20

Design, Synthesis, and Pharmacological Evaluation of Dual FXR-LIFR Modulators for the Treatment of Liver Fibrosis

Pasquale Rapacciuolo, Claudia Finamore, Cristina Di Giorgio, +16

Journal of Medicinal Chemistry

Liver <scp>GPBAR1</scp> Associates With Immune Dysfunction in Primary Sclerosing Cholangitis and Its Activation Attenuates Cholestasis in Abcb4−/− Mice

Cristina Di Giorgio, Ginevra Urbani, Silvia Marchianò, +17

Liver International