Exosomal CD73 from serum of patients with melanoma suppresses lymphocyte functions and is associated with therapy resistance to anti-PD-1 agents

Roberta Turiello, Mariaelena Capone, Elva Morretta, +8

Journal for ImmunoTherapy of Cancer

Serum CD73 is a prognostic factor in patients with metastatic melanoma and is associated with response to anti-PD-1 therapy

Roberta Turiello, Mariaelena Capone, Diana Giannarelli, +21

Journal for ImmunoTherapy of Cancer

Opposite effects of the FXR agonist obeticholic acid on Mafg and Nrf2 mediate the development of acute liver injury in rodent models of cholestasis

Adriana Carino, Michele Biagioli, Silvia Marchianò, +11

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids

Opposite EffectsHepatologyBiochemistryMedicineLiver Physiology +13

Transcriptome Analysis of Dual FXR and GPBAR1 Agonism in Rodent Model of NASH Reveals Modulation of Lipid Droplets Formation

Adriana Carino, Silvia Marchianò, Michele Biagioli, +10

Nutrients

Beneficial effects of UDCA and norUDCA in a rodent model of steatosis are linked to modulation of GPBAR1/FXR signaling

Silvia Marchianò, Michele Biagioli, Rosalinda Roselli, +9

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids

InflammationMetabolic SyndromeSignal TransductionOxysterolBeneficial Effects +10

Combinatorial therapy with BAR502 and UDCA resets FXR and GPBAR1 signaling and reverses liver histopathology in a model of NASH

Silvia Marchianò, Michele Biagioli, Elva Morretta, +10

Scientific Reports

ImmunologyPathologyFatty Liver DiseaseBile Acid ContentMetabolic Syndrome +22

Serum Bile Acid Levels Before and After Sleeve Gastrectomy and Their Correlation with Obesity-Related Comorbidities

Stefano De Vuono, Maria Anastasia Ricci, Elisa Nulli Migliola, +8

Obesity Surgery

ObesityMetabolic SyndromeBariatric SurgerySleeve GastrectomyBiliary Tract +7

Discovering the Biological Target of 5-epi-Sinuleptolide Using a Combination of Proteomic Approaches

Elva Morretta, Roberta Esposito, Carmen Festa, +3

Marine Drugs

Drug Repositioning for Fabry Disease: Acetylsalicylic Acid Potentiates the Stabilization of Lysosomal Alpha-Galactosidase by Pharmacological Chaperones

Maria Monticelli, Ludovica Liguori, Mariateresa Allocca, +7

International Journal of Molecular Sciences

Activation of GPBAR1 attenuates vascular inflammation and atherosclerosis in a mouse model of NAFLD-related cardiovascular disease

Michele Biagioli, Silvia Marchianò, Cristina Di Giorgio, +20

Biochemical Pharmacology