Denise C. Hegan

2-Hydroxyglutarate produced by neomorphic IDH mutations suppresses homologous recombination and induces PARP inhibitor sensitivity

Parker L. Sulkowski, Christopher D. Corso, Nathaniel D. Robinson et al. · Science Translational Medicine · 2017 · 550 citations

Genetics, Molecular Biology, Molecular Genetics +19

Inhibition of poly(ADP-ribose) polymerase down-regulates BRCA1 and RAD51 in a pathway mediated by E2F4 and p130

Denise C. Hegan, Yuhong Lü, Gregory C. Stachelek et al. · Proceedings of the National Academy of Sciences · 2010 · 206 citations · Full text

Differing patterns of genetic instability in mice deficient in the mismatch repair genes Pms2, Mlh1, Msh2, Msh3 and Msh6

Denise C. Hegan, Latha Narayanan, Frank R. Jirik et al. · Carcinogenesis · 2006 · 92 citations · Full text

Knockout Mouse, Genome Instability, Genetic Instability +15

The cytotoxicity of (−)-lomaiviticin A arises from induction of double-strand breaks in DNA

Laureen Colis, Christina M. Woo, Denise C. Hegan et al. · Nature Chemistry · 2014 · 80 citations · Full text

Genome Instability, Dna Damage, Natural Sciences +9

Nickel induces transcriptional down-regulation of DNA repair pathways in tumorigenic and non-tumorigenic lung cells

Susan E. Scanlon, Christine D. Scanlon, Denise C. Hegan et al. · Carcinogenesis · 2017 · 60 citations · Full text

Dna Damage, Molecular Biology, Heavy Metal Carcinogenesis +19