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The cytotoxicity of (−)-lomaiviticin A arises from induction of double-strand breaks in DNA

Laureen Colis, Christina M. Woo, Denise C. Hegan, Zhenwu Li, Peter M. Glazer, Seth B. Herzon

Nature Chemistry · 2014 · 84 citations · 38 references

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38

Methods in Enzymology , Vol

S P Colowick, M D Joshi, Jagannathan et al. · 1966 · 26.2K citations

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P53 Binding Protein 1 (53bp1) Is an Early Participant in the Cellular Response to DNA Double-Strand Breaks

Linda Schultz, Nabil Chehab, Asra Malikzay et al. · The Journal of Cell Biology · 2000 · 908 citations · Full text

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Bioactivation as a Model for Drug Design Bioreductive Alkylation

Harold W. Moore · Science · 1977 · 433 citations

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DNA double-strand breaks and alkali-labile bonds produced by bleomycin

Lawrence F. Povirk, Werner Wübker, Wolfgang Köhnlein et al. · Nucleic Acids Research · 1977 · 292 citations · Full text

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Expression of phosphorylated histone H2AX as a surrogate of cell killing by drugs that create DNA double-strand breaks.

Judit P. Banáth, Peggy L. Olive · PubMed · 2003 · 290 citations

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