LY2456302 is a novel, potent, orally-bioavailable small molecule kappa-selective antagonist with activity in animal models predictive of efficacy in mood and addictive disorders

Linda M. Rorick‐Kehn, Jeffrey M. Witkin, Michael A. Statnick, +18

Neuropharmacology

Psychoactive DrugPsychiatryFunctional SelectivityMedicineAnimal Models +5

Evidence for the preferential localization of Glutamate Receptor-1 subunits of AMPA receptors to the dendritic spines of medium spiny neurons in rat striatum

Q Chen, L. Veenman, Kelly L. Knopp, +5

Neuroscience

Synaptic PlasticityDendritic SpinesNeurophysiologyNeuroanatomySynaptic Transmission +10

Pungency of TRPV1 agonists is directly correlated with kinetics of receptor activation and lipophilicity

Daniel Ursu, Kelly L. Knopp, Bin Liu, +1

European Journal of Pharmacology

Molecular PharmacologySignal TransductionMolecular PhysiologyBiochemistryTrpv1 Agonists +7

Tetrodotoxin-Resistant Sodium Channels in Sensory Neurons Generate Slow Resurgent Currents That Are Enhanced by Inflammatory Mediators

Zhi‐Yong Tan, Andrew D. Piekarz, Birgit T. Priest, +5

Journal of Neuroscience

Synaptic TransmissionNeurotransmitterNeurotransmissionCellular NeurobiologyCellular Physiology +19

Synthesis and Pharmacological Characterization of C4-Disubstituted Analogs of 1<i>S</i>,2<i>S</i>,5<i>R</i>,6<i>S</i>-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylate: Identification of a Potent, Selective Metabotropic Glutamate Receptor Agonist and Determination of Agonist-Bound Human mGlu2 and mGlu3 Amino Terminal Domain Structures

James A. Monn, Lourdes Prieto, Lorena Taboada, +35

Journal of Medicinal Chemistry

Pharmacological CharacterizationPharmacotherapyExperimental PharmacologyCompound 2C4-disubstituted Analogs +16

An Allosteric Potentiator of the Dopamine D1 Receptor Increases Locomotor Activity in Human D1 Knock-In Mice without Causing Stereotypy or Tachyphylaxis

Kjell Svensson, Beverly A. Heinz, John M. Schaus, +29

Journal of Pharmacology and Experimental Therapeutics

The α2,3-selective potentiator of GABAA receptors, KRM-II-81, reduces nociceptive-associated behaviors induced by formalin and spinal nerve ligation in rats

Jeffrey M. Witkin, Rok Cerne, Paula G. Davis, +22

Pharmacology Biochemistry and Behavior

Pain MedicineSynaptic TransmissionNeuromodulation TherapiesAnesthetic MechanismMolecular Pain +15

Experimental design and reporting standards for improving the internal validity of pre-clinical studies in the field of pain: Consensus of the IMI-Europain consortium

Kelly L. Knopp, Carina Stenfors, Cathrine Baastrup, +17

Scandinavian Journal of Pain

Duloxetine in the long-term management of diabetic peripheral neuropathic pain: An open-label, 52-week extension of a randomized controlled clinical trial

Joachim Wernicke, Joel Raskin, A. Rosen, +5

Current Therapeutic Research

Broad spectrum efficacy with LY2969822, an oral prodrug of metabotropic glutamate 2/3 receptor agonist LY2934747, in rodent pain models

Michael P. Johnson, Mark Muhlhauser, Eric S. Nisenbaum, +9

British Journal of Pharmacology