Concepedia

LY2456302 is a novel, potent, orally-bioavailable small molecule kappa-selective antagonist with activity in animal models predictive of efficacy in mood and addictive disorders

Linda M. Rorick‐Kehn, Jeffrey M. Witkin, Michael A. Statnick, Elizabeth L. Eberle, Jamie H. McKinzie, Steven D. Kahl, Beth M. Forster, Conrad J. Wong, Xia Li, Robert S. Crile,

Neuropharmacology · 2013 · 153 citations · 54 references

DOI

Concepts

References

54

Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats.

G. Di Chiara, Assunta Impérato · Proceedings of the National Academy of Sciences · 1988 · 4.7K citations · Full text

, , +17

Opposing tonically active endogenous opioid systems modulate the mesolimbic dopaminergic pathway.

Rainer Spanagel, A. Herz, Toni S. Shippenberg · Proceedings of the National Academy of Sciences · 1992 · 1K citations

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Autoradiographic differentiation of mu, delta and kappa opioid receptors in the rat forebrain and midbrain

Alfred Mansour, Henry Khachaturian, M. E. Suzanne Lewis et al. · Pain · 1988 · 980 citations

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Mu, delta, and kappa opioid receptor mRNA expression in the rat CNS: An in situ hybridization study

Alfred Mansour, Charles A. Fox, Sharon Burke et al. · The Journal of Comparative Neurology · 1994 · 868 citations · Full text

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Psychotomimesis Mediated by κ Opiate Receptors

Andreas Pfeiffer, Victor Brantl, Albert Herz et al. · Science · 1986 · 858 citations

, , +16