Joan H. Carter

Synthesis and Pharmacological Characterization of C4-Disubstituted Analogs of 1<i>S</i>,2<i>S</i>,5<i>R</i>,6<i>S</i>-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylate: Identification of a Potent, Selective Metabotropic Glutamate Receptor Agonist and Determination of Agonist-Bound Human mGlu2 and mGlu3 Amino Terminal Domain Structures

James A. Monn, Lourdes Prieto, Lorena Taboada et al. · Journal of Medicinal Chemistry · 2015 · 61 citations

Medicine, Medicinal Chemistry, Pharmacology +16

Synthesis and Pharmacological Characterization of <i>C</i>4-(Thiotriazolyl)-substituted-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylates. Identification of (1<i>R</i>,2<i>S</i>,4<i>R</i>,5<i>R</i>,6<i>R</i>)-2-Amino-4-(1<i>H</i>-1,2,4-triazol-3-ylsulfanyl)bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid (LY2812223), a Highly Potent, Functionally Selective mGlu₂ Receptor Agonist

James A. Monn, Lourdes Prieto, Lorena Taboada et al. · Journal of Medicinal Chemistry · 2015 · 57 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +10

Intracellular Binding Site for a Positive Allosteric Modulator of the Dopamine D1 Receptor

Xushan Wang, Beverly A. Heinz, Yuewei Qian et al. · Molecular Pharmacology · 2018 · 38 citations · Full text

Medicine, Neurobiology, Pharmacology +17

Synthesis and Pharmacological Characterization of C4_β-Amide-Substituted 2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylates. Identification of (1<i>S,</i>2<i>S,</i>4<i>S,</i>5<i>R,</i>6<i>S</i>)-2-Amino-4-[(3-methoxybenzoyl)amino]bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid (LY2794193), a Highly Potent and Selective mGlu₃Receptor Agonist

James A. Monn, Steven S. Henry, Steven M. Massey et al. · Journal of Medicinal Chemistry · 2018 · 29 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +14

mGlu2/3 Agonist-Induced Hyperthermia: An In Vivo Assay for Detection of mGlu2/3 Receptor Antagonism and its Relation to Antidepressant-Like Efficacy in Mice

Scott D. Gleason, X. Li, A. Ian Smith et al. · CNS & Neurological Disorders - Drug Targets · 2013 · 28 citations

Medicine, Medicinal Chemistry, Pharmacology +14