A transforming mutation in the pleckstrin homology domain of AKT1 in cancer

John D. Carpten, Andrew L. Faber, Candice L. Horn, +20

Nature

Somatic VariantMedicinePleckstrin Homology DomainCancer GeneticsSystems Biology +4

The retinoblastoma gene product regulates progression through the G1 phase of the cell cycle

David W. Goodrich, Nan Ping Wang, Yuewei Qian, +2

Cell

Developmental BiologyCell RegulationCell DivisionG1 PhaseCell Proliferation +7

Crystal structure of the human PRMT5:MEP50 complex

Stephen Antonysamy, Zahid Bonday, Robert M. Campbell, +14

Proceedings of the National Academy of Sciences

ChromatinCrystal StructureProtein FunctionChromatin StructureBiochemistry +13

A retinoblastoma-binding protein related to a negative regulator of Ras in yeast

Yuewei Qian, Yi-Chun J. Wang, Robert E. Hollingsworth, +3

Nature

Protein FunctionSignal TransductionNegative RegulatorCell RegulationMolecular Regulation +9

Activated Polo-Like Kinase Plx1 Is Required at Multiple Points during Mitosis in <i>Xenopus laevis</i>

Yuewei Qian, E Erikson, Chuan Li, +1

Molecular and Cellular Biology

Secreted PCSK9 downregulates low density lipoprotein receptor through receptor-mediated endocytosis

Yuewei Qian, Robert J. Schmidt, Youyan Zhang, +14

Journal of Lipid Research

The critical role of the MAP kinase pathway in meiosis II in Xenopus oocytes is mediated by p90Rsk

Markus S. Schwab, Frédéric Taïeb, Andrea L. Lewellyn, +2

Current Biology

OocyteChromatinXenopus OocytesDevelopmental BiologySignal Transduction +13

The 2.5 Å Crystal Structure of the SIRT1 Catalytic Domain Bound to Nicotinamide Adenine Dinucleotide (NAD⁺) and an Indole (EX527 Analogue) Reveals a Novel Mechanism of Histone Deacetylase Inhibition

Xun Zhao, Dagart Allison, Bradley Condon, +9

Journal of Medicinal Chemistry

Crystal StructureAldo-keto ReductaseMolecular RegulationMolecular BiologyEpigenetics +18

Hippocampal AMPA Receptor Gating Controlled by Both TARP and Cornichon Proteins

Akihiko Kato, Martin B. Gill, Michelle T. Ho, +8

Neuron

Molecular PhysiologySignal TransductionCornichon ProteinsNeurophysiologyG Protein-coupled Receptor +7

Serum Proprotein Convertase Subtilisin Kexin Type 9 Is Correlated Directly with Serum LDL Cholesterol

William E. Alborn, Guoqing Cao, Holly E. Careskey, +5

Clinical Chemistry