Noah J Harris

Oncogenic mutations of PIK3CA lead to increased membrane recruitment driven by reorientation of the ABD, p85 and C-terminus

Meredith L. Jenkins, Harish Ranga-Prasad, Matthew AH Parson et al. · Nature Communications · 2023 · 71 citations · Full text

Disease-related mutations in PI3Kγ disrupt regulatory C-terminal dynamics and reveal a path to selective inhibitors

Manoj K Rathinaswamy, Zied Gaieb, Kaelin D. Fleming et al. · eLife · 2021 · 51 citations · Full text

Molecular Regulation, Immunology, Selective Inhibitors +20

HDX-MS-optimized approach to characterize nanobodies as tools for biochemical and structural studies of class IB phosphoinositide 3-kinases

Manoj Kumar Rathinaswamy, Kaelin D. Fleming, Udit Dalwadi et al. · Structure · 2021 · 31 citations · Full text

Hdx-ms-optimized Approach, Biochemistry, Protein Nanoparticles +8

The substrate specificity of the human TRAPPII complex’s Rab-guanine nucleotide exchange factor activity

Meredith L. Jenkins, Noah J Harris, Udit Dalwadi et al. · Communications Biology · 2020 · 27 citations · Full text

Molecular basis for differential activation of p101 and p84 complexes of PI3Kγ by Ras and GPCRs

Manoj K Rathinaswamy, Meredith L. Jenkins, Benjamin R. Duewell et al. · Cell Reports · 2023 · 26 citations · Full text