Regina Choy

Discovery of GDC-0853: A Potent, Selective, and Noncovalent Bruton’s Tyrosine Kinase Inhibitor in Early Clinical Development

James J. Crawford, Adam R. Johnson, Dinah Misner et al. · Journal of Medicinal Chemistry · 2018 · 240 citations · Full text

Tyrosine Kinase, Immunology, Biological Therapy +24

Amyloid precursor protein (APP) traffics from the cell surface via endosomes for amyloid β (Aβ) production in the <i>trans</i> -Golgi network

Regina Choy, Zhiliang Cheng, Randy Schekman · Proceedings of the National Academy of Sciences · 2012 · 221 citations · Full text

Retromer Mediates a Discrete Route of Local Membrane Delivery to Dendrites

Regina Choy, Minjong Park, Paul Temkin et al. · Neuron · 2014 · 133 citations · Full text

Membrane Formation, Dendritic Processing, Membrane Transport +7

Battling Btk Mutants With Noncovalent Inhibitors That Overcome Cys481 and Thr474 Mutations

Adam R. Johnson, Pawan Bir Kohli, Arna Katewa et al. · ACS Chemical Biology · 2016 · 132 citations · Full text

Thr474 Mutations, Drug Target, Tyrosine Kinase +18

GPR88 Reveals a Discrete Function of Primary Cilia as Selective Insulators of GPCR Cross-Talk

Aaron Marley, Regina Choy, Mark von Zastrow · PLoS ONE · 2013 · 72 citations · Full text

Neurotransmitter, Molecular Biology, D1 Dopamine Receptor +19