Lynne Howells

Inhibition of cyclo-oxygenase 2 expression in colon cells by the chemopreventive agent curcumin involves inhibition of NF-κB activation via the NIK/IKK signalling complex

Simon Plummer, Karen Holloway, Margaret M. Manson et al. · Oncogene · 1999 · 633 citations

Medicine, Oncology, Pharmacology +13

Characterization of metabolites of the chemopreventive agent curcumin in human and rat hepatocytes and in the rat in vivo, and evaluation of their ability to inhibit phorbol ester-induced prostaglandin E2 production.

Christopher R. Ireson, S Orr, Donald J. L. Jones et al. · PubMed · 2001 · 592 citations

Medicine, Biochemistry, Pharmacology +13

Phase I Randomized, Double-Blind Pilot Study of Micronized Resveratrol (SRT501) in Patients with Hepatic Metastases—Safety, Pharmacokinetics, and Pharmacodynamics

Lynne Howells, D.P. Berry, P.J. Elliott et al. · Cancer Prevention Research · 2011 · 432 citations · Full text

Medicine, Oncology, Pharmacology +16

Curcumin Combined with FOLFOX Chemotherapy Is Safe and Tolerable in Patients with Metastatic Colorectal Cancer in a Randomized Phase IIa Trial

Lynne Howells, Chinenye Iwuji, Glen R.B. Irving et al. · Journal of Nutrition · 2019 · 234 citations · Full text

Medicine, Oncology, Pharmacology +16

Involvement of Nrf2, p38, B-Raf, and Nuclear Factor-κB, but Not Phosphatidylinositol 3-Kinase, in Induction of Hemeoxygenase-1 by Dietary Polyphenols

Catherine Andreadi, Lynne Howells, Paul Atherfold et al. · Molecular Pharmacology · 2005 · 211 citations

Life Sciences, Biochemistry, Pharmacology +17