Concepedia

Author

Lynne Howells

University of LeicesterORCID

Also Known As

Howells, Lynne, L Howells, L M Howells, L. Howells, L. M. Howells, L.M. Howells, Lynne Howells, Lynne M HOWELLS, Lynne M Howells, Lynne M. Howells

86

Publications

5K

Citations

30

H-Index

59

Concepts

All Affiliations

University of LeicesterLeicester Royal InfirmaryMRC Toxicology UnitUniversity Hospitals of Leicester NHS TrustLeicester General Hospital
LH

About

Lynne Howells is an author at University of Leicester specializing in medicine, pharmacology, and cancer research.

Top Concepts

#ConceptH-IndexPublicationsCitations

1

Medicine

13

14

2.5K

2

Health Sciences

3

3

1.1K

3

Biochemistry

2

2

604

4

Allergy

1

1

17

5

Biostatistics

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1

13

Lynne Howells

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35

Publications

3.8K

Citations

24

H-Index

YearCitations

Inhibition of cyclo-oxygenase 2 expression in colon cells by the chemopreventive agent curcumin involves inhibition of NF-κB activation via the NIK/IKK signalling complex

Simon Plummer, Karen Holloway, Margaret M. Manson,

Oncogene

1999

632

Characterization of metabolites of the chemopreventive agent curcumin in human and rat hepatocytes and in the rat in vivo, and evaluation of their ability to inhibit phorbol ester-induced prostaglandin E2 production.

Christopher R. Ireson, S Orr, Donald J. L. Jones,

PubMed

2001

591

Phase I Randomized, Double-Blind Pilot Study of Micronized Resveratrol (SRT501) in Patients with Hepatic Metastases—Safety, Pharmacokinetics, and Pharmacodynamics

Lynne Howells, D.P. Berry, P.J. Elliott,

Cancer Prevention Research

2011

423

Curcumin Combined with FOLFOX Chemotherapy Is Safe and Tolerable in Patients with Metastatic Colorectal Cancer in a Randomized Phase IIa Trial

Lynne Howells, Chinenye Iwuji, Glen R.B. Irving,

Journal of Nutrition

2019

226

Involvement of Nrf2, p38, B-Raf, and Nuclear Factor-κB, but Not Phosphatidylinositol 3-Kinase, in Induction of Hemeoxygenase-1 by Dietary Polyphenols

Catherine Andreadi, Lynne Howells, Paul Atherfold,

Molecular Pharmacology

2005

210

Relevance of mitogen activated protein kinase (MAPK) and phosphotidylinositol-3-kinase/protein kinase B (PI3K/PKB) pathways to induction of apoptosis by curcumin in breast cells

Matthew Squires, E A Hudson, Lynne Howells,

Biochemical Pharmacology

2003

192

Curcumin inhibits cancer stem cell phenotypes in ex vivo models of colorectal liver metastases, and is clinically safe and tolerable in combination with FOLFOX chemotherapy

Mark I. James, Chinenye Iwuji, Glen R.B. Irving,

Cancer Letters

2015

179

Cancer chemoprevention: Evidence of a nonlinear dose response for the protective effects of resveratrol in humans and mice

Hong Cai, Edwina N. Scott, Abeer Othman A. Kholghi,

Science Translational Medicine

2015

175

Curcumin mediates oxaliplatin-acquired resistance reversion in colorectal cancer cell lines through modulation of CXC-Chemokine/NF-κB signalling pathway

Vicenç Ruiz de Porras, Sara Bystrup, Anna Martínez‐Cardús,

Scientific Reports

2016

131

Prolonged Biologically Active Colonic Tissue Levels of Curcumin Achieved After Oral Administration—A Clinical Pilot Study Including Assessment of Patient Acceptability

Glen R.B. Irving, Lynne Howells, Stewart Sale,

Cancer Prevention Research

2012

109

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