Allosteric Activators of Glucokinase: Potential Role in Diabetes Therapy

Joseph Grimsby, Ramakanth Sarabu, Wendy L. Corbett, +16

Science

Glucose AffinityGlycosylationMedicineInsulin ManagementDiabetes +13

Discovery of 2-[3,5-Dichloro-4-(5-isopropyl-6-oxo-1,6-dihydropyridazin-3-yloxy)phenyl]-3,5-dioxo-2,3,4,5-tetrahydro[1,2,4]triazine-6-carbonitrile (MGL-3196), a Highly Selective Thyroid Hormone Receptor β Agonist in Clinical Trials for the Treatment of Dyslipidemia

Martha J. Kelly, Sherrie Pietranico-Cole, J. Douglas Larigan, +16

Journal of Medicinal Chemistry

PharmacotherapyExperimental PharmacologyCentral Thyroid AxisPharmaceutical ChemistryPre-clinical Pharmacology +14

Characterization of Glucokinase Regulatory Protein-deficient Mice

Joseph Grimsby, John W. Coffey, Mark Dvorozniak, +7

Journal of Biological Chemistry

Null MicePathologyCellular PhysiologyInsulin SignalingMetabolic Syndrome +23

Discovery of Piragliatin—First Glucokinase Activator Studied in Type 2 Diabetic Patients

Ramakanth Sarabu, Fred T. Bizzarro, Wendy L. Corbett, +24

Journal of Medicinal Chemistry

GlycobiologyMetabolomic ProfilingPathologyDiabetic PatientsInsulin Signaling +19

Discovery, Structure−Activity Relationships, Pharmacokinetics, and Efficacy of Glucokinase Activator (2<i>R</i>)-3-Cyclopentyl-2-(4-methanesulfonylphenyl)-<i>N</i>-thiazol-2-yl-propionamide (RO0281675)

Nancy-Ellen Haynes, Wendy L. Corbett, Fred T. Bizzarro, +14

Journal of Medicinal Chemistry

Pharmaceutical ScienceGlycobiologyGlucose HomeostasisPharmacotherapyChemical Biology +20

Optimization of Benzodiazepinones as Selective Inhibitors of the X-Linked Inhibitor of Apoptosis Protein (XIAP) Second Baculovirus IAP Repeat (BIR2) Domain

Robert F. Kester, Andrew F. Donnell, Yan Lou, +29

Journal of Medicinal Chemistry

X-linked InhibitorXiap Bir3Drug TargetApoptosis ProteinXiap Bir3 Inhibitors +12

Platelet monoamine oxidase in Parkinson patients: effect of L-deprenyl therapy

D. H. Lee, Maria Lira Paula P. Mendoza, Mark Dvorozniak, +2

Journal of Neural Transmission - Parkinsons Disease and Dementia Section

MedicinePsychotropic MedicationPlatelet Monoamine OxidaseNeuropharmacologyPharmacotherapy +6

2,3-Disubstituted acrylamides as potent glucokinase activators

Achyutharao Sidduri, Joseph Grimsby, Wendy L. Corbett, +9

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryBioorganic ChemistryNatural SciencesBioconjugation2,3-Disubstituted Acrylamides +3

Identification of RO4597014, a Glucokinase Activator Studied in the Clinic for the Treatment of Type 2 Diabetes

Yimin Qian, Wendy L. Corbett, Steven J. Berthel, +15

ACS Medicinal Chemistry Letters

Metabolic DisorderGlycobiologyPathologyLead IdentificationMetabolic Remodeling +18