Natacha Bienvenu

Discovery of 2-[[2-Ethyl-6-[4-[2-(3-hydroxyazetidin-1-yl)-2-oxoethyl]piperazin-1-yl]-8-methylimidazo[1,2- <i>a</i> ]pyridin-3-yl]methylamino]-4-(4-fluorophenyl)thiazole-5-carbonitrile (GLPG1690), a First-in-Class Autotaxin Inhibitor Undergoing Clinical Evaluation for the Treatment of Idiopathic Pulmonary Fibrosis

Nicolas Desroy, Christopher Housseman, Xavier Bock et al. · Journal of Medicinal Chemistry · 2017 · 139 citations · Full text

Medicine, Pharmacokinetics, Pharmacology +8

Discovery and Optimization of an Azetidine Chemical Series As a Free Fatty Acid Receptor 2 (FFA2) Antagonist: From Hit to Clinic

Mathieu Pizzonero, Sonia Dupont, Marielle Babel et al. · Journal of Medicinal Chemistry · 2014 · 110 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +17

Discovery, Structure–Activity Relationship, and Binding Mode of an Imidazo[1,2-<i>a</i>]pyridine Series of Autotaxin Inhibitors

Agnès Joncour, Nicolas Desroy, Christopher Housseman et al. · Journal of Medicinal Chemistry · 2017 · 62 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +16

Discovery of GLPG1972/S201086, a Potent, Selective, and Orally Bioavailable ADAMTS-5 Inhibitor for the Treatment of Osteoarthritis

F. Brebion, Romain Gosmini, Pierre Deprez et al. · Journal of Medicinal Chemistry · 2021 · 56 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +17

Optimization of Selectivity and Pharmacokinetic Properties of Salt-Inducible Kinase Inhibitors that Led to the Discovery of Pan-SIK Inhibitor GLPG3312

Taouès Temal-Laib, Christophe Peixoto, Nicolas Desroy et al. · Journal of Medicinal Chemistry · 2023 · 20 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +15