Reginald Valdez

Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo

William E. Dowdle, Beat Nyfeler, Jane Nagel et al. · Nature Cell Biology · 2014 · 715 citations

Inflammation, Cell Autophagy, Signal Transduction +13

The Histone H3K79 Methyltransferase Dot1L Is Essential for Mammalian Development and Heterochromatin Structure

Brendan T. Jones, Hui Su, Audesh Bhat et al. · PLoS Genetics · 2008 · 387 citations · Full text

Histone Modifications, Dot1-mediated H3k79 Methylation, Epigenetic Change +22

The RSPO–LGR4/5–ZNRF3/RNF43 module controls liver zonation and size

Lara Planas‐Paz, Vanessa Orsini, Luke Boulter et al. · Nature Cell Biology · 2016 · 348 citations · Full text

Molecular Physiology, Hepatology, Liver Physiology +7

Functional roles of Lgr4 and Lgr5 in embryonic gut, kidney and skin development in mice

Bernd Kinzel, Monika Pikiolek, Vanessa Orsini et al. · Developmental Biology · 2014 · 97 citations

Knockout Mouse, Skin Development, Cell Lineage +11

Defective Autophagy and mTORC1 Signaling in Myotubularin Null Mice

Kristina M. Fetalvero, Yenyen Yu, Margaret Goetschkes et al. · Molecular and Cellular Biology · 2012 · 88 citations · Full text

Mitophagy, Cell Autophagy, Signaling Pathway +16