The RSPO–LGR4/5–ZNRF3/RNF43 module controls liver zonation and size

Lara Planas‐Paz, Vanessa Orsini, Luke Boulter, +30

Nature Cell Biology

Molecular PhysiologyHepatologyLiver PhysiologyRspo–lgr4/5–znrf3/rnf43 Module ControlsHepatotoxicity +5

YAP promotes proliferation, chemoresistance, and angiogenesis in human cholangiocarcinoma through TEAD transcription factors

Patricia Marti, Claudia Stein, Tanja Blumer, +17

Hepatology

YAP, but Not RSPO-LGR4/5, Signaling in Biliary Epithelial Cells Promotes a Ductular Reaction in Response to Liver Injury

Lara Planas‐Paz, Tianliang Sun, Monika Pikiolek, +36

Cell stem cell

Signal TransductionDevelopmental BiologyHepatologyLiver InjuryBiliary Epithelial Cells +12

AXIN2+ Pericentral Hepatocytes Have Limited Contributions to Liver Homeostasis and Regeneration

Tianliang Sun, Monika Pikiolek, Vanessa Orsini, +13

Cell stem cell

Hepatic DisordersHepatologyLiver PhysiologyPhysiologyHepatology Inflammation +11

Functional roles of Lgr4 and Lgr5 in embryonic gut, kidney and skin development in mice

Bernd Kinzel, Monika Pikiolek, Vanessa Orsini, +14

Developmental Biology

Knockout MouseSkin DevelopmentCell LineageDevelopmental BiologyMedicine +9

ZNRF3 and RNF43 cooperate to safeguard metabolic liver zonation and hepatocyte proliferation

Tianliang Sun, Stefano Annunziato, Sebastian Bergling, +27

Cell stem cell

HepatologyBiochemistryNatural SciencesLiver PhysiologyMetabolic Liver Zonation +9

Genome-wide screening in human kidney organoids identifies developmental and disease-related aspects of nephrogenesis

Rosemarie Ungricht, Laure Guibbal, Marie-Christine Lasbennes, +11

Cell stem cell

Renal FunctionDevelopmental BiologyEngineeringMedicineGenetics +9

Cell adhesion molecule KIRREL1 is a feedback regulator of Hippo signaling recruiting SAV1 to cell-cell contact sites

Atanu Paul, Stefano Annunziato, Bo Lü, +17

Nature Communications

Contact SitesFeedback RegulatorSignal TransductionSignaling PathwayCell Regulation +13

NIBR-LTSi is a selective LATS kinase inhibitor activating YAP signaling and expanding tissue stem cells in vitro and in vivo

Kenji Namoto, Clara Baader, Vanessa Orsini, +51

Cell stem cell

Signal TransductionDevelopmental BiologySignaling PathwayMedicineReceptor Tyrosine Kinase +8

Predictive role of repair enzymes in the efficacy of Cisplatin combinations in pancreatic and lung cancer.

Godefridus J. Peters, Abolfazl Avan, Mariëlle Gallegos Ruiz, +4

PubMed

PathologyDna Repair StatusRepair EnzymesCisplatin CombinationsTumor Biology +14