Christopher Houle

Discovery and Preclinical Profiling of 3-[4-(Morpholin-4-yl)-7 <i>H</i> -pyrrolo[2,3- <i>d</i> ]pyrimidin-5-yl]benzonitrile (PF-06447475), a Highly Potent, Selective, Brain Penetrant, and in Vivo Active LRRK2 Kinase Inhibitor

Jaclyn L. Henderson, Bethany L. Kormos, Matthew M. Hayward et al. · Journal of Medicinal Chemistry · 2014 · 178 citations · Full text

LRRK2 inhibitors induce reversible changes in nonhuman primate lungs without measurable pulmonary deficits

Marco A. S. Baptista, Kalpana Merchant, Ted Barrett et al. · Science Translational Medicine · 2020 · 123 citations

Blood gene expression signatures predict exposure levels

Pierre R. Bushel, Alexandra N. Heinloth, J. Li et al. · Proceedings of the National Academy of Sciences · 2007 · 119 citations · Full text

Genomic Markers, Profiling Algorithm, Genetics +20

Evaluation of Serum Bile Acid Profiles as Biomarkers of Liver Injury in Rodents

Lina Luo, Shelli Schomaker, Christopher Houle et al. · Toxicological Sciences · 2013 · 106 citations

Glycocholic Acid, Pathology, Toxicological Mechanism +19

Loss of Expression and Altered Localization of KAI1 and CD9 Protein Are Associated with Epithelial Ovarian Cancer Progression

Christopher Houle, Xiaoyu Ding, Julie F. Foley et al. · Gynecologic Oncology · 2002 · 80 citations

Altered Localization, Medicine, Pathology +5