Matthew D. Alexander

Discovery of CRBN E3 Ligase Modulator CC-92480 for the Treatment of Relapsed and Refractory Multiple Myeloma

Joshua D. Hansen, Matthew Correa, Mark A. Nagy et al. · Journal of Medicinal Chemistry · 2020 · 204 citations · Full text

Hematological Malignancy, Novel Therapy, Medicine +15

Birinapant (TL32711), a Bivalent SMAC Mimetic, Targets TRAF2-Associated cIAPs, Abrogates TNF-Induced NF-κB Activation, and Is Active in Patient-Derived Xenograft Models

Christopher A. Benetatos, Yasuhiro Mitsuuchi, Jennifer M. Burns et al. · Molecular Cancer Therapeutics · 2014 · 173 citations

Chemoprevention Strategy, Apoptosis, Immunology +22

Birinapant, a Smac-Mimetic with Improved Tolerability for the Treatment of Solid Tumors and Hematological Malignancies

Stephen M. Condon, Yasuhiro Mitsuuchi, Yijun Deng et al. · Journal of Medicinal Chemistry · 2014 · 149 citations

Surgical Oncology, Solid Tumors, Apoptosis +20

A Central Strategy for Converting Natural Products into Fluorescent Probes

Matthew D. Alexander, Michael D. Burkart, Michael S. Leonard et al. · ChemBioChem · 2006 · 79 citations

Engineering, Biomolecular Tool, Molecular Biology +19

Design and Synthesis of Novel Cereblon Binders for Use in Targeted Protein Degradation

Stephen H. Norris, Xiaochu Ba, Jayce Rhodes et al. · Journal of Medicinal Chemistry · 2023 · 41 citations · Full text

Protein Assembly, Peptide Engineering, Chemical Composition +19